Regulation of Cell Survival by Secreted Proneurotrophins

By Ramee Lee, P. Kermani, K. Teng, B. Hempstead. Science, 2001

1,714 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b470885a706f9855210ff1ed3e7510b5aff6892b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. B. Lu
2. L. Monteggia
3. L. Reichardt
4. Anita E. Autry
5. T. Rantamäki
6. M. Chao
7. Eero Castrén
8. B. Hempstead

In Molecular Biology

1. B. Lu
2. L. Reichardt
3. M. Chao
4. Eero Castrén
5. T. Rantamäki
6. D. Rifkin
7. Volkmar Lessmann
8. Anita E. Autry

Citations in the corpus

• Mouse and rat BDNF gene structure and expression revisited (2006, background): “Uncleaved precursor BDNF protein (pro-BDNF) has altered binding characteristics and distinct biological activity in comparison with mature BDNF protein (Lee et al., 2001; Teng et al., 2005).”
• The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma (2014, background): “NGF is formed by cleavage from Pro-NGF, which is the precursor protein form of NGF; however, the roles of Pro-NGF and NGF are not consistent; treatment with Pro-NGF in cervical ganglia neurons which express both of the NGF receptors p75NTR and tyrosine receptor kinase A (TrkA) leads to programmed ce”
• The GDNF family: Signalling, biological functions and therapeutic value (2002, background): “Interestingly, recent evidence indicates that secreted proneurotrophins are biologically activ”
• A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease (2005, background): “Production of 'proNGF' (a variant of 'mature' NGF) was measured because of reported association with cell los”
• Activation of p75NTR by proBDNF facilitates hippocampal long-term depression (2005, background): “In contrast, pro-neurotrophins bind p75 NTR with high affinit”
• Neurotrophins and their receptors: A convergence point for many signalling pathways (2003, background): “Surprisingly, pro-neurotrophins are more selective ligands for the p75 receptor than mature form”
• The yin and yang of neurotrophin action (2005, background): “In 2001, Hempstead and colleagues shattered the traditional view that these precursors are functionally inactive by showing that they promote cell deat”
• Sortilin is essential for proNGF-induced neuronal cell death (2004, background): “In contrast, proNGF selectively induces apoptosis through p75 NTR but not Trk”
• Making sense of latent TGFβ activation (2003, background): “Furthermore, it is interesting to speculate that proTGFβ performs a distinct signaling function from TGFβ (perhaps through integrin ligation) similar to the separate signaling capacities of proNGF and NGF (Lee et al., 2001).”
• Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers (2016, background): “This occurs through cleaving inactive growth factor precursors into their active form or through releasing active growth factors by ECM proteolysis.(54,188) Increased levels of growth factors support tissue remodeling by stimulating angiogenesis, vasculogenesis, and neurogenesis, all of which are cr”
• BDNF and activity-dependent synaptic modulation. (2003, background): “Hempstead and colleagues recently demonstrated that the proforms of NGF and BDNF can be secreted and cleaved extracellularly by plasmin and a number of metalloproteinases (Lee et al. 2002).”
• Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons (2004, result): “This result is consistent with previous studies demonstrating that constitutively secreted proBDNF is capable of being cleaved extracellularly by plasmin and metalloproteases (Lee et al., 2001).”
• Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease (2005, background): “Furthermore, individuals with a defect in activity-dependent secretion of proBDNF have impaired episodic memory (Lee et al. 2001) and declarative memory (Hariri et al. 2003).”
• The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity (2010, background): “The activation of p75 by pro-BDNF has been shown to induce neuronal atrophy and apoptosis, dendritic pruning and the induction of long-term depression (LTD) (Lee et al., 2001; Lu et al., 2005; Woo et al., 2005; Zagrebelsky et al., 2005).”
• Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “The significance of this precursor protein seems to be that the full-length proneurotrophins get folded (Heymach et al., 1996) and sorted (Lee et al., 2001) properly.”