Neurotrophins and their receptors: A convergence point for many signalling pathways

By M. Chao. Nature Reviews Neuroscience, 2003

2,285 citations recorded by the source corpus.

Subfields: Biomaterials, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/584fee531197d7bfb25d7dd944de5d508478619a

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In Biomaterials

In Cellular and Molecular Neuroscience

Citations in the corpus

Cellular and Molecular Mechanisms of Pain (2009, neutral): “Among its many cellular targets, NGF acts directly on peptidergic C fiber nociceptors, which express the high-affinity NGF receptor tyrosine kinase, TrkA, as well as the low-affinity neurotrophin receptor, p75 (Chao, 2003; Snider and McMahon, 1998).”
Brain-derived neurotrophic factor and its clinical implications (2015, background): “The secondary messengers which are activated in the spinal cord by BDNF signaling include the MAP/ERK pathway, proto-oncogene c-fos and nitric oxide (NO)-producing neurons [24–26].”
Microglia promote learning-dependent synapse formation through BDNF (2013, background): “…pro and mature forms of BDNF bind different receptors on the surface of neurons (p75/sortilin and tropomyosin-related kinase receptor B [TrkB], respectively) to affect different cellular processes (Chao, 2003), we asked whether, and in which form, BDNF might be produced and secreted by microglia.”
Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. (2007, background): “Nerve Growth Factor is the founding member of the neurotrophins, which are a family of secreted proteins essential for the proper development, patterning, and maintenance of the mammalian nervous system (Bothwell, 1995; Chao, 2003; Cohen, 1959; Dechant and Barde, 2002; Roux and Barker, 2002).”
Socioeconomic status and the brain: mechanistic insights from human and animal research (2010, background): “Licking and grooming of pups increases NMDA ( N -methyl- D -aspartate) receptor levels in the hippocampus and hippocampal expression of growth factors (brain-derived neurotrophic factor and basic fibroblast growth factor), which promote neuronal activation and synaptogenesis, respectivel”
Mouse and rat BDNF gene structure and expression revisited (2006, background): “All neurotrophins bind to p75NGFR receptor but selectively interact with their individual high-affinity protein kinase receptors of the trk (tropomyosin-related kinase) family (Kaplan and Miller, 2000; Chao, 2003; Teng and Hempstead, 2004).”
Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons (2004, background): “Brain-derived neurotrophic factor (BDNF) has been established to play critical roles in vertebrate nervous system and cardiovascular development and function (Tessarollo, 1998; Huang and Reichardt, 2001; Chao, 2003).”
Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “Binding of mature BDNF (mBDNF) to TrkB triggers tyrosine phosphorylation in its cytoplasmic domain, leading to activation of at least three signaling pathways: MEK–MAPK, phosphatidylinositol-3-kinase (PI3-K) and phospholipase C-g (PLC-g) (Kaplan and Miller, 2000; Chao, 2003; Huang and Reichardt, 200”
Neurotrophin-regulated signalling pathways (2006, background): “Several excellent reviews describe recent progress in understanding the developmental and functional roles of these proteins (Bibel & Barde 2000; Huang & Reichardt 2001; Patapoutian & Reichardt 2001; Sofroniew et al. 2001; Dechant & Barde 2002; Chao 2003; Chao & Lee 2004; Lu et al. 2005).”
Sortilin is essential for proNGF-induced neuronal cell death (2004, background): “NGF regulates cell survival and cell death via binding to two different receptors, TrkA and p75 NTR (ref”