BDNF and activity-dependent synaptic modulation.

By B. Lu. Learning & memory (Cold Spring Harbor, N.Y.), 2003

1,006 citations recorded by the source corpus.

It is widely accepted that neuronal activity plays a pivotal role in synaptic plasticity. Neurotrophins have emerged recently as potent factors for synaptic modulation. The relationship between the activity and neurotrophic regulation of synapse development and plasticity, however, remains unclear. A prevailing hypothesis is that activity-dependent synaptic modulation is mediated by neurotrophins. An important but unresolved issue is how diffusible molecules such as neurotrophins achieve local and synapse-specific modulation. In this review, I discuss several potential mechanisms with which neuronal activity could control the synapse-specificity of neurotrophin regulation, with particular emphasis on BDNF. Data accumulated in recent years suggest that neuronal activity regulates the transcription of BDNF gene, the transport of BDNF mRNA and protein into dendrites, and the secretion of BDNF protein. There is also evidence for activity-dependent regulation of the trafficking of the BDNF receptor, TrkB, including its cell surface expression and ligand-induced endocytosis. Further study of these mechanisms will help us better understand how neurotrophins could mediate activity-dependent plasticity in a local and synapse-specific manner.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/a4f380ffc03ba5e2894acb9ac89756d988fde369

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In Developmental Neuroscience

Citations in the corpus

The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses (2008, neutral): “Presynaptic expression of homeostatic plasticity in cortical circuits has not yet been reported in vivo, whereas postsynaptic forms have (Desai et al., 2002; Maffei et al., 2004; Goel and Lee, 2007).”
A common polymorphism in the brain‐derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS (2008, background): “Both forms predominantly undergo activity-dependent release (rather than predominant constitutive release like other neurotrophins) at central synapses (Lu, 2003), possibly by virtue of a ‘sorting motif’ in the ‘pro’ region of ProBDNF.”
Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “In addition to its prominent role in neuronal survival and differentiation during development, BDNF has emerged as a key regulator of synaptic plasticity and behavior (McAllister et al, 1999; Poo, 2001; Lu, 2003).”
Major depression after breast cancer: a review of epidemiology and treatment. (2008, background): “Levels of brain-derived neurotrophic factor, a trophic protein important in modulating neuronal synaptic plasticity and essential to long-term memory [89], are decreased in depressed patients [90,91] and can be increased with antidepressant treatment [92].”
Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice (2008, background): “BDNF is an important neurotrophic factor in regulating neuronal transmission (Lu, 2003), striatal neuronal survival (Baquet et al.”
Homeostatic synaptic plasticity: local and global mechanisms for stabilizing neuronal function. (2012, background): “BDNF is thought to be released as a function of pyramidal neuron activity, and activates Trk receptors on both pyramidal and interneurons (Lu 2003).”
TrkB signalling pathways in LTP and learning (2009, background): “Evidence for the activity-dependent regulation of BDNF transcription and secretio”
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression (2005, background): “An emerging concept is that synaptic plasticity is tightly controlled by neurotrophic factors, which themselves are produced and secreted in an activity-dependent manne”
Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons (2004, background): “However , it has also been established that the majority of BDNF released from neurons is attributable to activity - dependent secre - tion from the regulated secretory pathway rather than the consti - tutive secretory pathway ( Lu , 2003b ) .”
Determinants of the induction of cortical plasticity by non‐invasive brain stimulation in healthy subjects (2010, background): “BDNF is released in an activity dependant manner and has a significant role in promoting changes in synaptic efficacy (Lu, 2003; Bramham, 2008).”
The yin and yang of neurotrophin action (2005, background): “Indeed, recent studies support the emerging concept that the pro-domain of neurotrophins is crucial for intracellular trafficking and secretion, and can, therefore, significantly affect neurotrophin functio”
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity (2017, neutral): “1) (Foltran and Diaz 2016; Lu 2003).”