The yin and yang of neurotrophin action

By B. Lu, Petti T. Pang, N. Woo. Nature Reviews Neuroscience, 2005

1,353 citations recorded by the source corpus.

Subfields: Biomaterials, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b274fa4937f3cea0c5fe69314509bdac849d7380

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomaterials

1. Akira Yoshii
2. M. Constantine‐Paton
3. Keri Martinowich
4. B. Lu
5. L. Reichardt

In Cellular and Molecular Neuroscience

1. E. Nestler
2. R. Duman
3. B. Lu
4. Eero Castrén
5. T. Rantamäki
6. Keri Martinowich
7. V. Krishnan
8. H. Schmidt

In Molecular Biology

1. E. Nestler
2. B. Lu
3. V. Krishnan
4. M. Constantine‐Paton
5. Akira Yoshii
6. L. Reichardt
7. Eero Castrén
8. S. Russo

Citations in the corpus

• The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity (2010, background): “These data suggest that under conditions whereby pro-BDNF is secreted, its extracellular cleavage is of critical importance for its functional response (Lu et al., 2005; Martinowich et al., 2007; Yang et al., 2009a).”
• A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor (2014, background): “BDNF has been implicated in neural development and functioning, including neurogenesis, dendritic growth, and long-term potentiation of neurons (Altar, 1999; Gorski et al., 2003; Huang et al., 1999; Lu et al., 2005).”
• Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “Activation of p75NTR by proneurotrophins has been linked to the activation of apoptotic signaling and initiation of N-methyl-D-aspartic acid (NMDA) receptor-dependent synaptic depression in the hippocampus (Ibanez, 2002; Lu and Je, 2003; Barker, 2004; Lu et al, 2005).”
• Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease (2010, positive): “Accumulating evidence suggests that BDNF affects both E- and LLTP through both pre- and post-synaptic mechanisms and that both of these mechanisms are involved in learning and initiating activity-dependent tuning of developing circuits (Poo, 2001; Lu et al., 2005).”
• Neurotrophin-regulated signalling pathways (2006, background): “…of neuronal development and function, including synapse formation and synaptic plasticity (Lewin & Barde 1996; Bibel & Barde 2000; Kaplan & Miller 2000; Huang et al. 2001; Poo 2001; Shooter 2001; Sofroniew et al. 2001; Dechant & Barde 2002; Chao 2003; Huang & Reichardt 2003; Lu et al. 2005).”
• Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. (2007, background): “The G196A SNP of the Bdnf gene results in the substitution of Met in place of Val in the prodomain of BDNF (Lu et al., 2005).”
• New insights into BDNF function in depression and anxiety (2007, result): “Recent studies have demonstrated that proBDNF and mBDNF facilitate long-term depression (LTD) and long-term potentiation (LTP), respectively, implying opposing cellular function”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “In addition to BDNF and NT-3, NGF has been demonstrated to influence cell survival and synaptic plasticity in the adult brain (Lu et al., 2005).”
• BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity (2017, background): “Intracellular proteolytic cleavage of pro-BDNF may occur in the trans-Golgi network by constitutively released furin, or in intracellular secretory vesicles by regulated conver- tases (Lu et al. 2005).”
• Neurotrophin regulation of neural circuit development and function (2012, background): “surface expression of type A GABA receptors (GABA A Rs) in the dendrite (9).”
• Activation of p75NTR by proBDNF facilitates hippocampal long-term depression (2005, neutral): “These results support a provocative 'yin-yang' hypothesi”
• Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex (2006, background): “Members of this family are also homodimeric and have been shown to bind and signal through both homodimeric and heteromeric counterstructures (17, 18).”
• A common polymorphism in the brain‐derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS (2008, background): “Brain-derived neurotrophic factor (BDNF) has a variety of roles in development and in the adult has been shown in animal models (Aicardi et al. 2004) to modulate NMDAR-dependent LTP (Figurov et al. 1996) and LTD (Woo et al. 2005a).”
• GDNF, NGF and BDNF as therapeutic options for neurodegeneration. (2013, background): “Now the pro-neurotrophin forms are seen to have specific functions, often in direct opposition to the roles of their mature counterparts (Lu et al., 2005).”