Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease

By Shiyong Peng, J. Wuu, E. Mufson, Margaret Fahnestock. Journal of Neurochemistry, 2005

680 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/96e0e788019bde005324b7234ce2cf23b7487f1c

How researchers see this paper

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In Cellular and Molecular Neuroscience

1. T. Rantamäki
2. Eero Castrén
3. Bruce S. McEwen
4. K. Ebner
5. Nicolas Singewald
6. R. Duman

In Developmental Neuroscience

1. T. Rantamäki
2. Eero Castrén
3. Bruce S. McEwen
4. K. Ebner
5. Nicolas Singewald

In Physiology

1. Richard O'Brien
2. M. Kitazawa
3. Philip C. Wong
4. F. LaFerla
5. Michael T. Heneka

Citations in the corpus

• The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity (2010, background): “…is a matter of debate but several lines of evidence suggests that at least under pathological conditions and following neuronal activity the levels of endogenous pro-BDNF might be significant (Harrington et al., 2004; Lu et al., 2005; Peng et al., 2005; Matsumoto et al., 2008; Yang et al., 2009b).”
• Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease (2009, background): “BDNF is decreased within the brains, serum, and CSF of patients with mild cognitive impairment and AD and can even correlate with minimental state examination scores (30, 31).”
• Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus. (2007, neutral): “…Pezawas et al., 2004; Qiao et al., 1998; Rattiner et al., 2004; Tokuyama et al., 2000), and they have also been implicated in brain disorders that involve cognitive decline (Howells et al., 2000; Peng et al., 2005; Phillips et al., 1991; Saura et al., 2004; Tong et al., 2004; Zuccato et al., 2001).”
• Amyloid Precursor Protein Processing and Alzheimer’s Disease (2011, background): “First, the levels of brain-derived neurotrophic factor (BDNF) in the brains of patients with AD decrease (Lee et al. 2005, Peng et al. 2005), and BDNF infusion can improve cognitive function in aged primates (Nagahara et al. 2009).”
• GDNF, NGF and BDNF as therapeutic options for neurodegeneration. (2013, background): “2000; Holsinger et al., 2000; Peng et al., 2005), PD (Howells et al., 2000), HD (Zuccato et al., 2008), ALS (Nishio et al., 1998), Rett syndrome (Sun & Wu, 2006), schizophrenia (Favalli et al., 2012) and depression (Castren et al., 2007).”