Sortilin is essential for proNGF-induced neuronal cell death

By A. Nykjaer, Ramee Lee, K. Teng, Pernille Jansen, P. Madsen, M. Nielsen, C. Jacobsen, Marco Kliemannel, E. Schwarz, T. Willnow and 2 more. Nature, 2004

962 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4fa2d5495027e05d76bb9b3672f6f85331aec893

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. B. Lu
2. B. Hempstead
3. N. Woo
4. Petti T. Pang
5. L. Reichardt
6. M. Constantine‐Paton
7. Akira Yoshii
8. Keri Martinowich

In Molecular Biology

1. B. Lu
2. Petti T. Pang
3. B. Hempstead
4. N. Woo
5. L. Reichardt
6. Akira Yoshii
7. M. Constantine‐Paton

Citations in the corpus

• GDNF, NGF and BDNF as therapeutic options for neurodegeneration. (2013, background): “pro-neurotrophins (Nykjaer et al., 2004), but not the mature neurotrophins.”
• Activation of p75NTR by proBDNF facilitates hippocampal long-term depression (2005, result): “Indeed, a number of recent studies showed that pro-neurotrophins, by activating p75 NTR , promote apoptosis in the peripheral nervous syste”
• ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin (2005, methodology): “Rat primary Schwann cells were plated on poly-L-lysine-coated plates in DMEM supplemented with 10% FCS, glutamine, penicillin and streptomycin , and forskolin and bovine pituitary extract as described previously (Nykjaer et al., 2004).”