The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity

By Eero Castrén, T. Rantamäki. Developmental Neurobiology, 2010

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How researchers see this paper

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Brain on stress: How the social environment gets under the skin (2012, background): “This finding reinforces two important messages: (i) plasticity-facilitating treatments should be given within the framework of a positive behavioral or physical therapy intervention, and (ii) negative experiences during the window may even make matters worse (115).”
Individual differences in stress susceptibility and stress inhibitory mechanisms (2017, positive): “by targeted behavioral interventions combined with drugs that facilitate treatment efficacy by supporting plasticity mechanisms [13,14].”
Understanding resilience (2013, background): “BDNF acts through its two main receptors, TrkB and p75 (Castren and Rantamaki, 2010).”
Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “BDNF and TrkB levels are decreased in regions of the hippocampus in postmortem tissue taken from suicide victims or patients with MDD or in the serum of patients with MDD (Castrén et al., 2007; Castrén and Rantamäki, 2010; Thompson Ray et al., 2011).”