The GDNF family: Signalling, biological functions and therapeutic value

By M. S. Airaksinen, M. Saarma. Nature Reviews Neuroscience, 2002

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Novel functions and signalling pathways for GDNF (2003, background): “During recent years, evidence indicating that GDNF, NRTN and ARTN also act on SCG neurons has accumulated (reviewed by Airaksinen and Saarma, 2002).”
Pathogenetic mechanisms in thyroid follicular-cell neoplasia (2006, background): “Glial-derived neurotrophic factor (GDNF)-family ligands and GDNF-family receptor-α (GFRα) bind the extracellular domain of RET to induce tyrosine kinase autophosphorylation that activates several signalling pathways, including extracellular regulated kinase (ERK, also known as MAPK kinase 1 and 3), ”
Neurotrophins and their receptors: A convergence point for many signalling pathways (2003, background): “4 ), which is a common signalling receptor for GDNF-related ligands that also include artemin, neurturin and persephi”
Multiple roles of HDAC inhibition in neurodegenerative conditions (2009, background): “Notably, the use of GDNF gene delivery has been considered as a potential therapy for neurodegenerative diseases, including PD [95].”
Neurobiology of the incubation of drug craving (2011, positive): “These neurotrophic factors also play a significant role in synaptic plasticity during development as well plasticity events associated with learning and memory [63, 77].”