New insights into BDNF function in depression and anxiety

By Keri Martinowich, Husseini K. Manji, B. Lu. Nature Neuroscience, 2007

1,170 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/12ca21522e233e789df8e8f61e66ce9004697e9c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. L. Monteggia
2. Anita E. Autry
3. R. Duman
4. T. Rantamäki
5. G. Sanacora
6. P. Willner
7. Eero Castrén
8. John H. Krystal

In Developmental Neuroscience

1. L. Monteggia
2. Anita E. Autry
3. T. Rantamäki
4. P. Willner
5. Eero Castrén
6. G. Sanacora
7. M. Chao
8. R. Duman

Citations in the corpus

• The molecular neurobiology of depression (2008, critical): “First, a substantial number of preclinical studies either have failed to show these patterns of changes induced by stress and by antidepressants, or have shown the opposite effect”
• Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments (2019, background): “Several possible downstream targets of glucocorticoids have been examined, including BDNF, a major neurotrophic factor that contributes to the maintenance and survival of neurons, as well as activity dependent regulation of synapse number and function (Hedrick et al., 2016; Martinowich et al., 2007;”
• The neurobiology of psychedelic drugs: implications for the treatment of mood disorders (2010, background): “Deficits in these neuroplastic mechanisms have been implicated in the pathophysiology of depressio”
• The chronic mild stress (CMS) model of depression: History, evaluation and usage (2016, background): “The expression of CREB in the hippocampus is increased by chronic, but not acute administration of antidepressants of all classes (Nibuya et al., 1995; Duman and Monteggia, 2006; Martinowich et al., 2007).”
• Normal gut microbiota modulates brain development and behavior (2011, background): “Gut microbiota may also be able to modify expression of risk genes (16, 36) or be part of mechanisms that alter cognitive functions observed in patients with gastrointestinal diseases (37, 38).”
• Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “, 2007) or that deletion of BDNF and its precursor pro-BDNF results in distinct behavioral alterations in different brain areas (Martinowich et al., 2007); sufficient experimental evaluation of these proposals has not yet been undertaken.”
• Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior (2008, background): “While the functions of newborn neurons in the adult are largely elusive, there is increasing evidence that adult neurogenesis (17) and BDNF expression (29) in the dentate gyrus are involved in mood regulation.”
• The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity (2010, background): “These data suggest that under conditions whereby pro-BDNF is secreted, its extracellular cleavage is of critical importance for its functional response (Lu et al., 2005; Martinowich et al., 2007; Yang et al., 2009a).”
• Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate (2016, background): “A number of studies have indicated that decreased levels of BDNF are associated with depression and become enhanced following antidepressant treatment (Duman and Monteggia, 2006; Martinowich et al., 2007).”