Post-synaptic BDNF-TrkB Signaling in Synapse Maturation, Plasticity and Disease
By Akira Yoshii, M. Constantine‐Paton. Developmental Neurobiology, 2010
738 citations recorded by the source corpus.
Brain‐derived neurotrophic factor (BDNF) is a prototypic neurotrophin that regulates diverse developmental events from the selection of neural progenitors to the terminal dendritic differentiation and connectivity of neurons. We focus here on activity‐dependent synaptic regulation by BDNF and its receptor, full length TrkB. BDNF‐TrkB signaling is involved in transcription, translation, and trafficking of proteins during various phases of synaptic development and has been implicated in several forms of synaptic plasticity. These functions are carried out by a combination of the three signaling cascades triggered when BDNF binds TrkB: The mitogen‐activated protein kinase (MAPK), the phospholipase Cγ (PLC PLCγ), and the phosphatidylinositol 3‐kinase (PI3K) pathways. MAPK and PI3K play crucial roles in both translation and/or trafficking of proteins induced by synaptic activity, whereas PLCγ regulates intracellular Ca2+ that can drive transcription via cyclic AMP and a protein kinase C. Conversely, the abnormal regulation of BDNF is implicated in various developmental and neurodegenerative diseases that perturb neural development and function. We will discuss the current state of understanding BDNF signaling in the context of synaptic development and plasticity with a focus on the postsynaptic cell and close with the evidence that basic mechanisms of BDNF function still need to be understood to effectively treat genetic disruptions of these pathways that cause devastating neurodevelopmental diseases. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 2010
Subfields: Cellular and Molecular Neuroscience, Genetics, Geriatrics and Gerontology
View Paper: https://www.semanticscholar.org/paper/29933f0a1bdffe04857ddd076cac7479522e7e0b
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In Cellular and Molecular Neuroscience
Citations in the corpus
- Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders (2012, background): “Each of these signaling pathways confer the unique function of BDNF on cells (for review, see (Mattson, 2008; Yoshii and Constantine-Paton, 2010).”
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory (2019, background): “At the level of secretion from a neuron and effects on itself or neighboring cells, neurotrophins such as BDNF, TGF-β, and ApNT act through receptors such as TrkB or ApTrk, activating kinases including ERK and phosphoinositide 3-kinase (Yoshii and Constantine-Paton 2010; Zadran et al. 2010).”