The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior

By H. Schmidt, R. Duman. Behavioural Pharmacology, 2007

623 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/c65f3ed2bc7f8b9e1e313aaf00fa5da6b3e0ef17

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

Citations in the corpus

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation (2011, neutral): “13) (analysis of variance (ANOVA), F(1,26) , 1; mean freezing, 34.”
Glutamate NMDA receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure (2011, neutral): “In contrast to the rapid actions of ketamine, chronic (21 d) administration of typical antidepressants is required to produce similar behavioral actions in these paradigms (11).”
Adult neurogenesis and the olfactory system. (2009, background): “Neurotrophic factors, particularly BDNF and VEGF, are important for the neurogenic mechanisms of antidepressants and environment (Rossi et al., 2006; Castren et al., 2007; Warner-Schmidt and Duman, 2007).”
Immune Influence on Adult Neural Stem Cell Regulation and Function (2009, neutral): “growth factors such as VEGF or BDNF, each also known to promote neurogenesis through their direct actions on NSC and NPCs (Ma et al., 2009; Schmidt and Duman, 2007; Segi-Nishida et al., 2008).”
Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases (2013, background): “BDNF is among the most well studied neurotrophins and has been shown to have a specific role in maturation and integration of newborn neurons in the adult hippocampus (Schmidt and Duman, 2007).”
Epigenetic regulation of neurogenesis in the adult mammalian brain (2011, background): “One of the best known targets of MeCP2 is brain-derived neurotrophic factor (BDNF), which has been implicated in regulating several aspects of adult hippocampal neurogenesis, including proliferation of neural progenitors (Li et al., 2008b) and development of newborn neurons (Schmidt & Duman, 2007).”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, neutral): “Within the niche, a plethora of extracellular factors regulate adult neural progenitors and their development through activation of diverse intracellular signaling cascades (Schmidt and Duman, 2007; Zhao et al., 2008).”
The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression (2009, background): “2008; Koo and Duman 2008) along with decreases in the levels of BDNF in brain regions associated with depression (Schmidt and Duman 2007; Fuchs et al. 2004).”