Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex

By D. Toy, D. Kugler, M. Wolfson, T. V. Bos, Jesse L. Gurgel, J. Derry, J. Tocker, J. Peschon. Journal of Immunology, 2006

603 citations recorded by the source corpus.

Subfields: Immunology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/8b0d14160f23da6687cb0cadd50e2ecfb4e37045

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. V. Kuchroo
2. T. Korn
3. M. Oukka
4. E. Bettelli
5. Y. Iwakura
6. Wenjun Ouyang
7. Yan Zheng
8. J. Kolls

In Oncology

1. V. Kuchroo
2. Shizuo Akira
3. Taro Kawai

In Pathology and Forensic Medicine

1. V. Kuchroo
2. E. Bettelli
3. T. Korn
4. M. Oukka
5. Y. Iwakura
6. J. Kolls
7. H. Ishigame

Citations in the corpus

• IL-17 and Th17 Cells. (2009, background): “Moreover, although the differentiation conditions necessary for Th17 cells to yield maximum expression of IL-17A and IL-17F are similar, there are differences in the conditions for the maximum upregulation of the other cytokines associated with the Th17 phenotype, as has been reported for IL-22 (132”
• The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, positive): “Toy and colleagues have recently shown that IL-17RA and IL-17RC can be coimmunopreciptated and that the cotransfection of IL-17RA and IL-17RC results in effective binding of IL-17A and IL-17F and signaling as measured by the induction of CXCL1 (Toy et al., 2006).”
• Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. (2009, background): “IL-17RC Is Highly Expressed in Colonic Epithelial Cells Two receptor molecules, IL-17RA and IL-17RC, reportedly bind IL-17A and IL-17F (Toy et al., 2006; Zheng et al., 2008).”
• Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. (2010, background): “IL-17F is also produced by Th17 cells and binds to the same receptors (IL-17RA and IL-17RC) (Toy et al., 2006; Zheng et al., 2008).”