BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
By P. Kowiański, G. Lietzau, E. Czuba, Monika Waskow, A. Steliga, Janusz Morys. Cellular and molecular neurobiology, 2017
1,194 citations recorded by the source corpus.
Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and extensively studied neurotrophins in the mammalian brain. Among its prominent functions, one can mention control of neuronal and glial development, neuroprotection, and modulation of both short- and long-lasting synaptic interactions, which are critical for cognition and memory. A wide spectrum of processes are controlled by BDNF, and the sometimes contradictory effects of its action can be explained based on its specific pattern of synthesis, comprising several intermediate biologically active isoforms that bind to different types of receptor, triggering several signaling pathways. The functions of BDNF must be discussed in close relation to the stage of brain development, the different cellular components of nervous tissue, as well as the molecular mechanisms of signal transduction activated under physiological and pathological conditions. In this review, we briefly summarize the current state of knowledge regarding the impact of BDNF on regulation of neurophysiological processes. The importance of BDNF for future studies aimed at disclosing mechanisms of activation of signaling pathways, neuro- and gliogenesis, as well as synaptic plasticity is highlighted.
View Paper: https://www.semanticscholar.org/paper/4ba31284eee1a2708c9750938408effd619b0d62
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Citations in the corpus
- Rett Syndrome and Fragile X Syndrome: Different Etiology With Common Molecular Dysfunctions (2021, methodology): “Multiple models for FXS have been generated in flies (Drozd et al., 2018), zebrafish (Vaz et al., 2019), rat (Kulkarni and Sevilimedu, 2020), and mice (Bakker et al., 1994; Mientjes et al., 2006; Dahlhaus, 2018).”
- Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020, background): “Intracellular proteolytic cleavage of proBDNF may occur by the subtilisin-kexin family of endoproteases such as furin, or in intracellular vesicles by convertases [69,70] (Figure 1).”
- Temporal Interference Stimulation Enhances Neural Regeneration (2026, unknown): “BDNF is an immediate upstream regulator of ERK1/2 via tyrosine phosphorylation [ 126 ], and it is known to play a role in electrically-induced neurogenesis, differentiation, and plasticity both in vitro [ 29, 127 ] and in vivo [ 101, 128–133 ].”