A common polymorphism in the brain‐derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS

By B. Cheeran, P. Talelli, F. Mori, G. Koch, A. Suppa, M. Edwards, H. Houlden, Kailash Bhatia, R. Greenwood, John C. Rothwell. Journal of Physiology, 2008

721 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Neurology, Polymers and Plastics

View Paper: https://www.semanticscholar.org/paper/68a89e9a95d18cec339f563f72196834ae57941d

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Citations in the corpus

Determinants of the induction of cortical plasticity by non‐invasive brain stimulation in healthy subjects (2010, methodology): “…et al. 2002 rTMS 0.1 Hz rTMS (SI: 120% RMT) for ∼30 min in the presence of ischemic arm block d-amphetamine ↑ M1 facilitation with nerve block alone, but ↓M1 LTP-like response to rTMS + nerve block Genetics Cheeran et al. (2008) TBS + PAS25 ms cTBS (300 pulses) and iTBS (600 pulses) at 80% AMT.”
Plasticity during stroke recovery: from synapse to behaviour (2009, background): “It is even conceivable that differences in plasticity mechanisms between individuals that are due to BDNF gene polymorphisms could result in altered levels of plasticity after strok”
Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning (2010, positive): “It has also been presumed that tDCS strengthens synaptic connections (Nitsche et al., 2003b, 2004; Cheeran et al., 2008), through a mechanism similar to long-term potentiation (LTP), a cellular correlate of learning and memory (Bliss and Collingridge, 1993; Martin et al., 2000; Rioult-Pedotti et…”
Inter-individual variability in response to non-invasive brain stimulation paradigms. (2014, neutral): “Several reasons have been put forward for the considerable variability in the response to NIBS protocols, such as time of day [35], anatomical aspects as cortical thickness [36], coil orientation [37], genetic variation [38].”
tDCS-enhanced motor and cognitive function in neurological diseases (2014, positive): “Previous studies have demonstrated differential responses to both TMS and tDCS in carriers of the BDNF Val66Met polymorphism in the motor system (see for example (Cheeran et al., 2008; Fritsch et al., 2010; Witte et al., 2012).”
The role of interneuron networks in driving human motor cortical plasticity. (2013, background): “A number of studies have noted that the effects of TBS protocols can occasionally differ from those originally reported (Martin et al. 2006; Cheeran et al. 2008; McAllister et al. 2011; Goldsworthy et al. 2012; Hasan et al. 2012) and that individual responses can be considerably variable (Gentner…”