Role of oxygen radicals in DNA damage and cancer incidence

By M. Valko, Mário Izakovič, M. Mazúr, C. Rhodes, J. Telser. Molecular and Cellular Biochemistry, 2004

1,817 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/b207e5a187ace10cfc4ab1c2ed12fb88d85b9e6e

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Citations in the corpus

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis (2009, background): “The HO• attacks DNA strands when it is produced adjacent to cellular and mitochondrial DNA causing the addition of DNA bases new radicals, which lead to the generation of a variety of oxidation products (11).”
Size-dependent toxicity of metal oxide particles--a comparison between nano- and micrometer size. (2009, background): “ive rise to necrosis and apoptosis (Valko et al., 2004).”
Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants (2024, background): “Electron transfer reactions are among the most common chemical reactions in living systems (Valko et al. 2004; Jomova et al. 2022).”
The Role of Metallothionein in Oxidative Stress (2013, background): “Free radicals are known to play a dual role in biological systems, because they can be considered as beneficial or deleterious [3].”
Free radicals and antioxidants in normal physiological functions and human disease. (2007, background): “However, antioxidant protection therapy in cancer patients should be used only with caution since its effects depend on the stage at which it is introduced (Dreher & Junod, 1996; Valko et al., 2004).”
Oxidative Stress: Harms and Benefits for Human Health (2017, background): “Hydrolyzed DNA bases are common byproducts of DNA oxidation and are considered one of the most relevant events in chemical carcinogenesis [14, 22].”
Biomarkers of oxidative damage in human disease. (2006, background): “Oxidative DNA damage seems to relate to an increased risk of cancer development later in life (150, 151).”
Pulmonary Oxidative Stress, Inflammation and Cancer: Respirable Particulate Matter, Fibrous Dusts and Ozone as Major Causes of Lung Carcinogenesis through Reactive Oxygen Species Mechanisms (2013, background): “neoplasms, diabetes mellitus, atherosclerosis and various neurodegenerative diseases [24–28].”
Heavy Metals Toxicity and the Environment (2012, background): “Accumulating evidence also suggests that ROS play a major role in the mediation of metal-induced cellular responses and carcinogenesis [225–227].”
Mechanism and Health Effects of Heavy Metal Toxicity in Humans (2019, background): “When OH reacts with guanine, a nitrogenous base of nucleic acids, it leads to the generation of 8-oxo-7,8-dihydro-20-deoxyguanosine (8-oxo-dG) and 2,6-diamino-5-formamido-4-hydroxypyrimidine (FAPy-G), in which the former is a good marker for oxidative damage [23].”
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. (2014, background): “OH could be also generated by photolytic decomposition of alkylhydroperoxides (447).”
Studies on free radicals, antioxidants, and co-factors (2007, background): “In both steps, molecular oxygen is reduced, forming the superoxide anion followed by the generation of hydrogen peroxide (Valko et al 2004).”
Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. (2009, background): “Several studies have reported the in vivo and in vitro accumulation of 8-OH-dG as well as other lesions with advancing age, both in nuclear and mitochondrial DNA [83].”
Metals, oxidative stress and neurodegenerative disorders (2010, positive): “The superoxide radical participates in the Haber–Weiss reaction [17]”
Biochemistry of Free Radicals and Antioxidants (2010, neutral): “…and macrophages during inflammatory cell activation [5,6] (iv) as by-products of mitochondrial catalyzed electron transport reactions, (v) by cytochrome P450 metabolism and the enzyme xanthine oxidase, which catalyzes the reaction of hypoxanthine to xanthine and xanthine to uric acid [7].”
Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes. (2005, background): “[7] Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J.”