Metals, oxidative stress and neurodegenerative disorders

By K. Jomová, D. Vondrakova, Michael Lawson, M. Valko. Molecular and Cellular Biochemistry, 2010

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The role of oxidative stress during inflammatory processes (2013, background): “, through enzymatic- and metal-catalyzed (Fenton) reactions (Jomova et al., 2010).”
Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “In AD, iron deposition has been demonstrated to show the association with oxidative stress, which causes increased protein and DNA oxidation, and inactivation of the human brain muscarinic cholinergic receptor required for memory (Jomova et al., 2010; Salvador et al., 2010; Fawcett et al., 2002).”
The Role of Oxidative Stress in Parkinson’s Disease (2013, background): “Conversely, depletion of GSH in the SN results in selective decrease of mitochondrial complex I activity likely via thiol oxidation of critical residues leading to marked reduction in overall mitochondrial function [90–93].”
The Adverse Effects of Air Pollution on the Nervous System (2012, background): “The brain is especially vulnerable to oxidative stress injury because of its high metabolic activity, its low activity of antioxidant enzymes (superoxide dismutase and catalase), its low content of endogenous radical scavengers, such as vitamin C, its high cellular content of lipids and proteins, an”