Free radicals and antioxidants in normal physiological functions and human disease.

By M. Valko, D. Leibfritz, J. Moncol’, M. Cronin, M. Mazúr, J. Telser. International Journal of Biochemistry and Cell Biology, 2007

14,153 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/29ce36c50318cd7125df89ba405b519edc465aee

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Citations in the corpus

Oxidative stress and male infertility--a clinical perspective. (2008, background): “This allows for normal oxidative metabolism to occur without damaging the cells, while still allowing for normal ROS-mediated cellular responses such as destruction of infectious pathogens and intracellular signalling (Valko et al., 2007).”
Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION) (2010, background): “However, under pathological conditions (such as cancer, atherosclerosis, hypertension and arthritis), which are associated with the generation of ROS, iron may effectively be released from ferritin (49, 72).”
Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond. (2013, background): “It is important to know not only how ROS signaling in diseases affects function, but also how ROS initiate/propagate cellular signaling in homeostatic conditions as well (Valko et al., 2007).”
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal (2014, background): “The accumulation of lipid peroxidation by-product has been extensively studied and implicated in many toxic tissue injuries and in pathological processes.”
A review on the dietary flavonoid kaempferol. (2011, background): “Because oxidative stress is known to play an important role in some neurodegenerative disorders [40, 41] it makes sense to think that the antioxidant activity of kaempferol participates in its neuroprotective activity [284].”
Human health effects of air pollution. (2008, background): “In addition, they can interfere with signaling pathways within cells (Valko et al., 2006).”
The Role of Oxidative Stress in Parkinson’s Disease (2013, background): “In the presence of reducedmetalssuchasferrous iron(Fe2+),H2O2 canbe convertedbytheFentonreaction into thehighlyreactive hydroxyl radical, the most harmful of all ROS [23].”
Acute exercise and oxidative stress: a 30 year history (2009, background): “ies reporting null findings for glutathione redox status [53,68,107,108,123,124] may be partially related to the timing of sampling, as GSSG is rapidly reduced in vivo by way of glutathione reductase [5], in addition to the trained status of the subjects [108] or an insufficient intensity of exercis”
Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target? (2019, background): “Decreasing the amount of free radicals in our organism may impede some essential defense mechanisms such as apoptosis, phagocytosis, and detoxification [157,158].”
Activity of phenolic compounds from plant origin against Candida species (2015, background): “There are some nutrients present in oods that can help to protect and strength the body, at greater r lesser degree (Devasagayam et al., 2004; Murray and Pizzorno, 998; Singh et al., 2004; Valko et al., 2007).”
The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “They therefore are not only end products and remnants of lipid peroxidation processes but also may act as “second cytotoxic messengers” for the primary reactions [2].”
Mechanisms of nanotoxicity: Generation of reactive oxygen species (2014, background): “[40] Valko M, Leibfritz D, Moncol J, et al.”
First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid (2018, background): “Precisely, superoxide anion and hydrogen peroxide have been reported to act as mitogens, thereby promoting the rate of DNA replication and cell proliferation in a variety of cultured cells.(9,10) Nonetheless, in excess amounts, oxygen-derived radicals are very harmful to living organisms.”
Determination of Antioxidants by DPPH Radical Scavenging Activity and Quantitative Phytochemical Analysis of Ficus religiosa (2022, methodology): “The following formula was used to compute the percentage of antioxidants or RSA [19]: % of antioxidant activity= [(Ac−As) ÷Ac] × 100 where: Ac—Control reaction absorbance; As—Testing specimen absorbance.”
Arsenic: toxicity, oxidative stress and human disease (2011, background): “Malondialdehyde (MDA) and 4‐hydroxy‐trans‐2‐nonenal (HNE) are the most abundant aldehydes generated from the oxidation of LDL and possess mutagenic and carcinogenic properties (Valko et al., 2005, 2007).”