Novel mechanisms of natural antioxidant compounds in biological systems: involvement of glutathione and glutathione-related enzymes.

By R. Masella, Roberta Di Benedetto, R. Varì, C. Filesi, C. Giovannini. Journal of Nutritional Biochemistry, 2005

1,114 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/8193fc1534c2b22d587ab776a0e4f443c7cc4dee

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Citations in the corpus

Glutathione dysregulation and the etiology and progression of human diseases (2009, background): “Overexpression of specific glutathione S-transferases can also affect chemoresistance, whereas polymorphisms that decrease glutathione S-transferase activity are associated with elevated risk of developing certain cancers (Balendiran et al., 2004; Masella et al., 2005).”
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants (2015, background): “Glutathione, an intracellular multifunctional non-enzymatic antioxidant known for its role as a major redox (thiol-disulphide) buffer of the cell, is abundant in cytosol (1–11 mM), nuclei (3–15 mM), and mitochondria (5–11 mM) [166].”
Studies on free radicals, antioxidants, and co-factors (2007, background): “It is abundant in cytosol, nuclei, and mitochondria, and is the major soluble antioxidant in these cell compartments (Masella et al 2005).”
Oxidative Stress and Antioxidant Defense (2012, background): “GSH protects cells against apoptosis by interacting with proapoptotic and antiapoptotic signaling pathways.(94) It also regulates and activates several transcription factors, such as AP-1, NF-kB, and Sp-1.”
A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding (2009, background): “Furthermore, compounds such as glutathione (1–15 mM) [122, 290] are present at much higher concentrations in vivo than those attainable by polyphenols (*1–10 lM), and have much higher affinity for Cu than polyphenols.”
Free radicals and antioxidants in normal physiological functions and human disease. (2007, background): “The main protective roles of glutathione against xidative stress are (Masella et al., 2005): (i) glutathione s a cofactor of several detoxifying enzymes against xidative stress, e.g. glutathione peroxidase (GPx), gluathionetransferase and others; (ii) GSH participates in mino acid transport through…”
Biochemistry of Free Radicals and Antioxidants (2010, positive): “It is abundant in cytosol, nuclei, and mitochondria, and is the major soluble antioxidant in these cell compartments [51].”
Bioavailability of the Polyphenols: Status and Controversies (2010, background): “However, in the last decade, the mode of action of these compounds has turned out to be more complex than originally expected [8–11].”
Metals, oxidative stress and neurodegenerative disorders (2010, positive): “GSH in the nucleus maintains the redox state of critical protein sulphydryls that are necessary for DNA repair and expression [64].”
Dietary Polyphenols and Their Biological Significance (2007, background): “These protective mechanisms include scavenging or detoxification of reactive oxygen species (ROS), blocking ROS production, sequestration of transition metals, as well as enzymatic and nonenzymatic antioxidant defenses produced in the body, that is, endogenous [4,5], and others supplied with the die”