Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.

By D. Zorov, M. Juhaszova, Steven J. Sollott. Physiological Reviews, 2014

4,703 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/edea48e79e47e3764ed91570f775c441d780ef88

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In Molecular Biology

In Pathology and Forensic Medicine

Michael R Hamblin

Citations in the corpus

Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation (2018, background): “This process is characterized by a self-amplifying feedback loop called “ROS-induced ROS release” (RIRR) (49).”
Mitochondrial dynamics in health and disease: mechanisms and potential targets (2023, background): “26 The IMM carries several enzymes that control ROS production, including superoxide dismutase (SOD), which catalyze the dismutation of superoxide radicals (O 2) into molecular oxygen and hydrogen peroxide, and glutathione peroxidase (GPX), which catalyzes the reduction of hydrogen peroxide to…”
Oxidative Stress in Human Pathology and Aging: Molecular Mechanisms and Perspectives (2022, background): “Ionizing radiations (IR) induce double-stranded breaks by high-energy damage to the sugar backbone of DNA, and also through free radicals generated in cells—mostly •OH from water [22].”
Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity (2023, background): “ROS normally function as cellular messengers in redox signaling events when their concentrations are kept relatively low [108].”
Mitochondrial membrane potential (2017, background): “ΔΨm is implicated in many additional functions, adding further complexity and diversity to the role of mitochondria in cellular homeostasis, including the mitochondrial quality control, ROS generation, MPT pore stabilization and maintenance of the retrograde signaling through mitochondrial export of”
The Role of Oxidative Stress in Neurodegenerative Diseases (2015, background): “·OH is known to be one of the most reactive ROS that are mainly responsible for the cytotoxic effects of ROS [7] ·OH can be generated from H2O2 and O2 - and is catalyzed by iron ions through the Fenton reaction that refers to Fe-mediated decomposition of H2O2 [9].”
Mitochondrial dysfunction in pathophysiology of heart failure (2018, background): “, the opening of mPTP, increased mitochondrial oxidative stress, collapse of mitochondrial membrane potential, impaired ATP production, and necrosis of cardiomyocytes (16, 18, 20, 95).”
Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects (2021, background): “Finally, an imbalance in the intake, neutralization, and outflow of ROS and associated triggers in particular cell signaling pathways can lead to oxidative and reductive stressors, which can cause a range of illnesses or even cell organismal death [50].”
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance (2021, background): “The formation of mtROS due to proton leakage takes place under normal respiratory conditions but can be greatly enhanced in response to stress [14,15].”
Reperfusion injury and reactive oxygen species: The evolution of a concept (2015, background): “throughout the mitochondrial networks [290].”
Mitochondrial dysfunction: mechanisms and advances in therapy (2024, background): “335 Upon exposure to reactive oxygen or nitrogen species, [4Fe-4S] 2 + clusters in mitochondrial respiratory proteins are oxidized and may result in reversible aconitase inactivation, which impairs the inhibition of ROS production though affecting mitochondrial metabolic ﬂ ux.”
Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements (2019, background): “Numerous approaches have been developed to administer ROS and ROS producing agents in vitro in cell cultures, which would enhance ROS levels and ultimately cause cellular damage [176,177].”