8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

By A. Valavanidis, T. Vlachogianni, Constantinos Fiotakis. Journal of Environmental Science And Health Part C - Environmental Carcinogenesis & Ecotoxicology Reviews, 2009

1,921 citations recorded by the source corpus.

Subfields: Cancer Research, Health, Toxicology and Mutagenesis, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b9f5968001c78eea826b842e1856cb620bf1a634

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Citations in the corpus

• Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles (2016, background): “Hydroxyl radical (OH•), one of the highly potent radicals, and is known to react with all components of DNA causing DNA single strand breakage via formation of 8- hydroxyl-2′-deoxyguanosine (8-OHdG) DNA adduct (Pilger and Rüdiger, 2006; Valavanidis et al., 2009).”
• Oxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target? (2019, background): “One of the biomarkers that have gained increased attention is 8-hydroxy-2′-deoxyguanosine (8-OHdG), which represents one of the prevailing forms of free radical-induced oxidative DNA lesions [74].”
• Is depression associated with increased oxidative stress? A systematic review and meta-analysis. (2015, neutral): “It has recognized mutagenic properties and has been linked to — among others — the development of cancer (Valavanidis et al., 2009).”
• A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illness. (2011, background): “The assay of 8-OHdG in urine is a biomarker for oxidative DNA damage and more general for O&NS (Wu et al., 2004; Valavanidis et al., 2009).”
• ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “These compounds are widely considered as markers of endogenous oxidative DNA damage as well as a risk factor for cancer development [38].”
• Mechanisms of nanotoxicity: Generation of reactive oxygen species (2014, background): “8-OHdGhasalsobeen used as a risk factor for many diseases including cancer [65].”