Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer.

By N. Khansari, Y. Shakiba, M. Mahmoudi. Recent Patents on Inflammation & Allergy Drug Discovery, 2009

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Oxidative stress, aging, and diseases (2018, background): “Moreover, macrophages, platelets, fibroblasts, and cancer cells are a major source of angiogenic factors (ie, fibroblast growth factor, vascular endothelial growth factor, and prostaglandins-E1 and E2), which increase the production of RONS and, subsequently, increase the risk of cancer.(62) The mut”
The Role of Resveratrol in Cancer Therapy (2017, background): “Oxidative stress plays a dominant part in the causation of carcinogenesis [51].”
Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action (2022, background): “ROSinduced DNA damage results in induction/replication errors, transcriptional arrest, and/or genomic instability allied with carcinogenesis (Federico et al., 2007; Khansari et al., 2009).”
Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents (2012, background): “Recently, synthesis of novel chalcone derivatives and their SAR on ARE induction identified 2-trifluoromethyl-2′-methoxychalone (8) as a potent activator of Nrf2.”