C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE
By A. Reboldi, Caroline Coisne, Dirk Baumjohann, F. Benvenuto, D. Bottinelli, S. Lira, Antonio Uccelli, A. Lanzavecchia, B. Engelhardt, F. Sallusto. Nature Immunology, 2009
1,206 citations recorded by the source corpus.
Subfields: Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/20ae7384a8fa0c140711dcc31fdbbc539709d4b6
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In Immunology
- F. Sallusto
- C. Iadecola
- A. Lanzavecchia
- J. Anrather
- L. Sorokin
- B. Engelhardt
- Rafi Ahmed
- Bali Pulendran
In Oncology
Citations in the corpus
- International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors (2014, neutral): “On the other hand, recombinant smCKBP did not alter disease in EAE or collageninduced arthritis models.”
- Neuroinflammation: The Devil is in the Details (2016, neutral): “In this example, there is activation of CNS glia, cytokine and chemokine production, infiltration of peripheral immune cells, and presence of autoreactive T-cells (Samoilova et al. 1998; Reboldi et al. 2009).”
- The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF (2011, neutral): “The CCR6-CCL20 axis is essential for the entry of T H 17 cells into the CNS in the early phase of EA”
- Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells (2009, background): “25 ), which is also required for their migration into the central nervous syste”
- The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction (2009, background): “The first molecular evidence for T cell migration into the CNS via the choroid plexus was provided by a recent study demonstrating that Th17 cells may penetrate the BCSFB via CCR6 binding to CCL20 produced by choroid plexus epithelial but not endothelial cells in rodents and man [119] and specifical”
- Recruitment of Beneficial M2 Macrophages to Injured Spinal Cord Is Orchestrated by Remote Brain Choroid Plexus (2013, neutral): “The M2-educative property of the CP route seems to contradict the suggested role of CP entry in EAE induction (Reboldi et al., 2009).”
- The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “, CCL9, CCL20) also attracts T cell subsets to the brain, which has particularly been demonstrated in studies of autoimmune diseases (Oukka and Bettelli, 2018; Reboldi et al., 2009).”