Functional specialization of interleukin-17 family members.
By Y. Iwakura, H. Ishigame, S. Saijo, S. Nakae. Immunity, 2011
1,285 citations recorded by the source corpus.
Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F share the highest amino acid sequence homology, they perform distinct functions; IL-17A is involved in the development of autoimmunity, inflammation, and tumors, and also plays important roles in the host defenses against bacterial and fungal infections, whereas IL-17F is mainly involved in mucosal host defense mechanisms. IL-17E (IL-25) is an amplifier of Th2 immune responses. The functions of IL-17B, IL-17C, and IL-17D remain largely elusive. In this review, we describe the identified functions of each IL-17 family member and discuss the potential of these molecules as therapeutic targets.
Subfields: Immunology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/dc8f718d3ab20838ec4977fd7745ba1dd67e7c0c
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In Pathology and Forensic Medicine
Citations in the corpus
- Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer (2013, background): “role in tumor pathogenesis and treatment remains controversial.(64,65) Recently, gemcitabine and 5-FU were shown to activate the inflammasome pathway in MDSCs, leading to IL-1b production, which, in turn, induced IL-17 secretion by CD4 T-cells and blunted the anticancer efficacy of chemotherapy.”
- The maternal interleukin-17a pathway in mice promotes autismlike phenotypes in offspring (2016, methodology): “To determine if IL-17a acts on receptors in the mother or the fetus to induce the MIA phenotype, we injected poly(I:C) into IL-17Ra WT, HET or KO mothers that had been bred to IL-17Ra WT or HET males (39).”