T follicular helper (TFH) cells in normal and dysregulated immune responses.

By C. King, S. Tangye, C. Mackay. Annual Review of Immunology, 2008

695 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/42c0ae172b583360d812f0fd1916f7254927e3cc

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In Immunology

1. Jacques Banchereau
2. V. Kuchroo
3. V. Pascual
4. A. Luster
5. T. Korn
6. M. Oukka
7. A. Palucka
8. Di Yu

Citations in the corpus

• AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity1 (2009, background): “An MPL-based adjuvant has been found to specifically activate local follicular Th cells that are thought to be directly associated with the generation of B cell memory (61, 62).”
• IL-17 and Th17 Cells. (2009, background): “In the current understanding, T follicular helper cells express CXCR5 and thus respond to the lymph follicle– associated chemokine CXCL13 and home to and help establish the light zone of GCs, where they give cognate help to B cells that have undergone immunoglobulin isotype switching and somatic hyp”
• Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion (2011, background): “Recently, CD4+ T cells present in B cell folli- cles, named T follicular helper (Tfh) cells, have been established as a T helper (Th) cell subset specialized for providing help to B cells in GCs (Fazilleau et al., 2009; King et al., 2008).”
• Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. (2016, background): “Follicular helper T cells represent a large subset of effector T cells in lymphoid tissues and provide help to B cells.(28,29) They support the differentiation of antigen-specific B cells into memory and plasma cells.”
• Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells. (2008, background): “Another subset of CD4 T cells, Tfh cells, promotes the differentiation of B cells into high-affinity antibody-secreting cells within germinal centers (King et al., 2008).”
• Differentiation of Effector CD4 T Cell Populations (2010, neutral): “Some labs have also described TGF-β-producing Th3 cells (278), IL-10-producing TR1 (279) cells, IL-9-producing Th9 cells (280, 281), and T follicular helper Tfh cells (31, 44, 45) as separate lineages.”
• The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. (2009, background): “…despite having a very distinct cell function compared to other effector T cells, they have a phenotype that is only distinguished from non-Tfh effectors by a quantitative increase in the expression of CXCR5, CXCR4, PD-1, ICOS, IL-21 and other molecules (King et al., 2008; Vinuesa et al., 2005b).”
• Molecular mechanism and function of CD40/CD40L engagement in the immune system (2009, background): “GC B cells residing in the light zone are called centrocytes and are characterized by the expression of CXCR5 (102).”