Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells.
By E. Klechevsky, R. Morita, Maochang Liu, Y. Cao, Sebastien Coquery, L. Thompson-Snipes, F. Brière, D. Chaussabel, G. Zurawski, A. Palucka and 3 more. Immunity, 2008
653 citations recorded by the source corpus.
Subfields: Dermatology, Immunology
View Paper: https://www.semanticscholar.org/paper/c9e6630d212e75c08a3b69dea1c072c8353b5ae6
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In Dermatology
In Immunology
Citations in the corpus
- Vaccine Adjuvants: Putting Innate Immunity to Work (2010, background): “For example, dermal DCs and Langerhans cells play distinctive roles in adaptive immunity (Klechevsky et al., 2008).”
- Skin immune sentinels in health and disease (2009, background): “In addition, human Langerhans cells have been shown to preferentially induce the differentiation of T H 2 cells and can prime and cross-prime naive CD8 + T cell”
- Cancer immunotherapy via dendritic cells (2012, neutral): “However, other human DCs, such as epidermal Langerhans cell”
- Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion (2011, background): “Multiple factors are probably involved in this process, including DC subsets that prime naive CD4+ T cells (Klechevsky et al., 2008), cytokines secreted by DCs (Deenick et al., 2010; Dienz et al., 2009; Schmitt et al., 2009) or other cell types including neighboring Th cells (Nurieva et al., 2008;…”
- Dendritic-cell-based therapeutic cancer vaccines. (2013, background): “In particular, Langerhans cells (LCs) specialize in priming CD8 T cell immunity, whereas interstitial (dermal) CD14 DCs promote humoral immunity (Klechevsky et al., 2008).”
- Human inflammatory dendritic cells induce Th17 cell differentiation. (2013, background): “Several DC subsets have been identified in human skin: dermal CD1a DCs and CD14 DCs and epidermal Langerhans cells (Klechevsky et al., 2008).”
- Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells (2010, background): “Using HLA-DR and CD1a expression as a phenotypic definition of in vitro HSC/HPC-derived DCs (Klechevsky et al., 2008), we found that this culture system generated 30–50% of Lin HLA-DR+ CD1a+ cells, which included a small percentage of the desired DNGR-1+ BDCA3+ double-positive subset (Fig.”