Mechanisms of stem cell self-renewal.

By Shenghui He, Daisuke Nakada, S. Morrison. Annual Review of Cell and Developmental Biology, 2009

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Metabolic requirements for the maintenance of self-renewing stem cells (2014, background): “Increased PI3K activity leads to increases in cellular phosphatidyl inositol-3,4-bisphosphate (PtdIns(4,5)P2) and PtdIns-3,4,5-trisphosphate (PtdIns(3,4,5)P3) levels.”
Cancer stem cells: impact, heterogeneity, and uncertainty. (2012, background): “Stem cell properties and selfrenewal mechanisms change with age (He et al., 2009; Levi and Morrison, 2008).”
Building muscle: molecular regulation of myogenesis. (2012, background): “Cellular identity during development is further defined by intrinsic mechanisms such as the ability to self-renew and the capacity to prevent mitotic senescence or DNA damage (He et al. 2009).”
mTOR: from growth signal integration to cancer, diabetes and ageing (2010, background): “Tissue-specific stem cells help to maintain organ function by replacing differentiated cells that are undergoing turnover as well as those that have succumbed to damage (for a comprehensive review, see Ref”
Cancer stem cells: an evolving concept (2012, background): “It is interesting to note that many of these interactomes are shared by multiple stem cell type”
Tracking adult stem cells (2011, background): “Self-renewal is not unique to stem cells, as fully differentiated cells such as activated B and T lymphocytes can also undergo self-renewal”