Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
By Isabel Beerman, Deepta Bhattacharya, Sasan Zandi, Mikael Sigvardsson, Irving L. Weissman, David Bryder, Derrick J. Rossi. Proceedings of the National Academy of Sciences of the United States of America, 2010
705 citations recorded by the source corpus.
Subfields: Hematology, Immunology
View Paper: https://www.semanticscholar.org/paper/0b56341978afc62b0faf5a7c02214f97b8920c81
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Hematology
- S. Morrison
- Irving L. Weissman
- Derrick J. Rossi
- Benjamin L. Ebert
- A. Wagers
- W. Pang
- Margaret A. Goodell
- Lei Ding
In Immunology
Citations in the corpus
- Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age (2011, background): “In mice, small numbers of myeloid-biased HSC can be found among balanced-potential HSC in young 2-mo-old mice (8, 11, 12), suggesting that the young mouse HSC pool may contain lineagebiased clones that compete for niches and expansion signals.”
- Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells (2015, background): “2010) and in the ratio of myeloid to lymphoid cells that they generate upon transplantation into irradiated mice (Muller-Sieburg et al. 2002; Dykstra et al. 2007; Kent et al. 2009; Beerman et al. 2010; Challen et al. 2010; Morita et al. 2010).”
- Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions (2015, neutral): “…patterns of blood reconstitution in single cell transplantation assays are explained by selection of particular HSC clones (Copley et al., 2012), and the myeloid bias associated with old age by a shift in clonal dominance with over-representation of myeloid-biased HSCs (Beerman et al., 2010).”
- SLAM family markers resolve functionally distinct subpopulations of hematopoietic stem cells and multipotent progenitors (2013, background): “HSCs are also heterogeneous with respect to the ratio of myeloid to lymphoid cells that they generate upon transplantation into irradiated mice (Müller-Sieburg et al., 2002; Dykstra et al., 2007; Kent et al., 2009; Beerman et al., 2010; Challen et al., 2010; Morita et al., 2010) and with respect to ”
- Aging of the Innate Immune System (2010, background): “have shown recently that this is the result of the clonal expansion of myeloid biased HSCs [7 ].”
- Inflammation and aging: signaling pathways and intervention therapies (2023, background): “This leads to a reduction in the number of precursors for T and B cells with increasing age.(108,109) Taken together, with aging, the number of HSCs increases, while their function including self-renewal and clonogenicity, decreases.”
- Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal (2014, background): “The myeloid dominance is caused partly by a shift in the clonal composition of the HSC compartment (Beerman et al., 2010; Challen et al., 2010; Cho et al., 2008) but also reflects diminished differentiation capacity of individual HSCs (Dykstra et al., 2011).”
- Causes, consequences, and reversal of immune system aging. (2013, neutral): “21–23), it is now appreciated that the number of lymphoid-biased stem cells declines with age concomitant with an increase in myeloid-biased HSCs (19).”