Remyelination in the CNS: from biology to therapy

By Robin J. M. Franklin, C. ffrench-Constant. Nature Reviews Neuroscience, 2008

1,531 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/c0b1546bdda00806e5e65aca937a3f7404ce7e3e

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In Developmental Neuroscience

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Citations in the corpus

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. (2009, background): “How might the negative regulatory role of the canonical Wnt pathway help to explain the pathology of demyelinating disease? Delayed remyelination due to Wnt pathway dysregulation in OLPs could lead to chronic demyelination by OLPs then missing a ‘‘critical window’’ for differentiation (Miller and Mi”
Chordin-induced lineage plasticity of adult SVZ neuroblasts after demyelination (2010, positive): “A local endogenous pool of OPCs is apparently involved in repopulating and remyelinating demyelinated lesion”
The pathobiology of vascular dementia (2013, positive): “In turn, excess intracellular Ca2+ activates protease dependent processes that lead to microtubule fragmentation and perturbation of axonal flow (Franklin and Ffrench-Constant, 2008; Matute and Ransom, 2012).”
CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination (2010, neutral): “A body of previous work has provided evidence—indirect but persuasive—that remyelinating oligodendrocytes are derived from adult OLPs/NG2 cells (Franklin and ffrench-Constant, 2008).”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “most efficient cells at remyelinating demyelinated axons (77).”
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis (2011, background): “Thus, inflammatory mediators (such as ROS or RNS) must be able to circumvent any protective barrier that myelin might represen”
Origin of new glial cells in intact and injured adult spinal cord. (2010, background): “Demyelinated axons are vulnerable to degeneration, and rapid remyelination is important not only to regain conductance but also to avoid further neurodegeneration (Franklin and Ffrench-Constant, 2008).”