Metabolic Plasticity in Stem Cell Homeostasis and Differentiation
By C. Folmes, P. Dzeja, Timothy J. Nelson, Andre Terzic. Cell Stem Cell, 2012
663 citations recorded by the source corpus.
Plasticity in energy metabolism allows stem cells to match the divergent demands of self-renewal and lineage specification. Beyond a role in energetic support, new evidence implicates nutrient-responsive metabolites as mediators of crosstalk between metabolic flux, cellular signaling, and epigenetic regulation of cell fate. Stem cell metabolism also offers a potential target for controlling tissue homeostasis and regeneration in aging and disease. In this Perspective, we cover recent progress establishing an emerging relationship between stem cell metabolism and cell fate control.
Subfields: Cancer Research, Molecular Biology, Surgery
View Paper: https://www.semanticscholar.org/paper/8b638e2f0cab42668190b432a6ee7c532f860ff2
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In Cancer Research
In Molecular Biology
Citations in the corpus
- The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “The central importance of metabolism in reprogramming and self-renewal has recently caught the attention of the stem cell community, with most discoveries dating back to recent years only (reviewed in (Folmes et al., 2012; Zhang et al., 2012; Xu et al., 2013; Bukowiecki, Adjaye & Prigione, 2014) and”