Designing materials to direct stem-cell fate

By M. Lutolf, P. Gilbert, Helen M. Blau. Nature, 2009

1,406 citations recorded by the source corpus.

Proper tissue function and regeneration rely on robust spatial and temporal control of biophysical and biochemical microenvironmental cues through mechanisms that remain poorly understood. Biomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful artificial microenvironments in which to study and instruct stem-cell fate both in culture and in vivo. Further synergism of cell biological and biomaterials technologies promises to have a profound impact on stem-cell biology and provide insights that will advance stem-cell-based clinical approaches to tissue regeneration.

Subfields: Biomedical Engineering, Cell Biology

View Paper: https://www.semanticscholar.org/paper/8b7de1bb8ec0e70a5ec4b6a9bd0e7aedeaeb4f7a

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Citations in the corpus

Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration (2011, background): “Such discrepancies might have important implications in understanding the physiology of the muscle stem cell niche, notably by physical constraints to the maintenance of stem cell properties (Gilbert et al., 2010; Lutolf et al., 2009).”
Extracellular Matrix Degradation and Remodeling in Development and Disease (2011, background): “Together, by changing the ECM composition and topography, and thus the niche environment, ECM dynamics may be integrated into the regulatory network 16 Cite this article as Cold Spring Harb Perspect Biol 2011;3:a005058 that modulates the stem cell differentiation processes (Lutolf et al. 2009).”
Extracellular matrix: a dynamic niche component during cancer progression (2012, neutral): “1, stage 8; Engler et al., 2006; Lutolf et al., 2009; Gilbert et al., 2010).”
The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease (2014, background): “Indeed, a wealth of work has shown that the mechanical microenvironment can have dramatic consequences for stem cell fate (Lutolf et al., 2009).”
Tracking adult stem cells (2011, background): “In vitro culture The study of isolated adult stem cells in culture has practical advantages for their study in situ, for example to obtain a detailed description of stem-cell behaviour or growth factor requirement (Schroeder, 2008; Lutolf et al, 2009).”
The extracellular matrix at a glance (2010, background): “These scaffolds, combined with colonies of seeded stem cells, can reconstitute normal tissues with reasonable fidelity (Lutolf et al., 2009).”