Rejuvenation of regeneration in the aging central nervous system
By J. Ruckh, Jing-Wei Zhao, J. Shadrach, P. van Wijngaarden, T. N. Rao, A. Wagers, Robin J. M. Franklin. Cell Stem Cell, 2012
637 citations recorded by the source corpus.
SUMMARY Remyelination is a regenerative process in the central nervous system (CNS) that produces new myelin sheaths from adult stem cells. The decline in remyelination that occurs with advancing age poses a significant barrier to therapy in the CNS, particularly for long-term demyelinating diseases such as multiple sclerosis (MS). Here we show that remyelination of experimentally-induced demyelination is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis. Restored remyelination in old animals involves recruitment to the repairing lesions of blood-derived monocytes from the young parabiotic partner, and preventing this recruitment partially inhibits rejuvenation of remyelination. These data suggest that enhanced remyelinating activity requires both youthful monocytes and other factors, and that remyelination-enhancing therapies targeting endogenous cells can be effective throughout life.
Subfields: Developmental Neuroscience, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/07a181ca942972e2f2f895cb7e37af34e315e5d0
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Citations in the corpus
- Macrophages are required for neonatal heart regeneration. (2014, positive): “In skeletal muscle, regeneration following toxic injury depends on monocyte/macrophage stimulation of myogenic proliferation (33) and remyelination in the aging central nervous system is stimulated by recruitment of young monocytes (32).”
- Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis (2014, neutral): “Parabiosis was performed as previously described (Ruckh et al., 2012).”
- Growth Differentiation Factor 11 is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy (2013, neutral): “…parabiosis is a powerful model to determine whether circulating factors can alter tissue function (Balsam et al., 2004; Brack et al., 2007; Conboy et al., 2005; Eggan et al., 2006; Ruckh et al., 2012; Sherwood et al., 2004; Villeda et al., 2011; Wagers et al., 2002; Wright et al., 2001).”