Immunity to fungal infections

By L. Romani. Nature reviews. Immunology, 2004

1,180 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases, Small Animals

View Paper: https://www.semanticscholar.org/paper/a9adfc859b9a67e232c65fc9a741b895b2cfd9b4

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Citations in the corpus

IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance (2007, background): “strictly dependent on high levels of fungal growth [ 10 ] and further preventing Th1 functioning.”
Dectin-1 is required for β-glucan recognition and control of fungal infection (2006, neutral): “dtd" [ ]> Infections with normally nonpathogenic fungi such as Candida albicans are an emerging problem resulting from modern medical interventions and the increasing prevalence of acquired immunodeficienc”
INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, positive): “This is borne out in the pervasive induction of mixed CAM/AAM and Th1/Th2/Th17 responses in models of experimental fungal infection, in which protection has been associated with productive dectin-1-mediated signal activation and Th1/Th17mediated responses, whereas increased fungal burdens and poorer”
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “…during infection with L. major, T. brucei, T. cruzi, P. berghei, P. falciparum, and T. gondii, suggesting that multiple TLRs orchestrate the protective responses (Adachi et al., 2001; Bafica et al., 2006; Coban et al., 2007; Kropf et al., 2004; Mun et al., 2003; Ropert and Gazzinelli, 2004).”
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells (2007, background): “albicans is a dimorphic organism that can take either a yeast form (spherical morphology) or hyphal form (rod morphology); these forms have different T cell–polarizing capacities (in terms of T H 1 or T H 2 polarization”
Candida albicans morphogenesis and host defence: discriminating invasion from colonization (2011, neutral): “The cell wall therefore represents an ideal immunological target to discriminate self from non-self, and consequently the majority of fungal PAMPs (pathogen-associated molecular patterns) that activate and modulate immune responses are cell wall component”
Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity (2012, background): “, and are enriched for memory cells specific for pathogens encountered through those tissue”
Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms (2006, background): “Candidiasis can range from a mild superficial infection of the skin and mucosa to severe disseminated systemic disease (Naglik et al ., 2004; Romani, 2004).”
The Role of TLR2 in Infection and Immunity (2012, background): “Generation of a dominant TH1-cell response is required for most protective immune responses to fungi (Romani, 2004).”
Aflatoxins: A Global Concern for Food Safety, Human Health and Their Management (2017, background): “The major aflatoxins are B1, B2, G1, and G2, which can poison the body through respiratory, mucous or cutaneous routes, resulting in overactivation of the inflammatory response (Romani, 2004).”
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome (2012, background): “Many pattern-recognition receptors, such as Toll-like receptors (TLRs) and C-type lectin receptors, have been linked to antifungal immunity through the sensing of pathogen-associated molecular patterns (PAMPs) and the induction of signaling pathways that regulate gene transcriptio”
IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses (2013, background): “…consequences of the absence of lung CD11b+ DCs in an infection model dependent on Th17 cell responses such as the fungal pathogen A. fumigatus, a prevalent envi- ronmental fungus that causes potentially lethal infections in immunosuppressed in- dividuals (Hohl and Feldmesser, 2007; Romani, 2004).”
Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. (2010, background): “Because immunocompromised people and cortisone-treated mice are highly susceptible (Odds, 1988; Romani, 2004; Saijo et al., 2007), it is thought that acquired immunity is important for defense against this microorganism (Romani, 1999).”
Fusarium Infections in Immunocompromised Patients (2007, background): “More recently, the role of Toll-like receptors in the innate immune recognition of fungi has been recognized (94), and although little is known about fusariosis and Toll-like receptors, this system is likely important in invasive fusariosis as well.”
Dectin-1: a signalling non-TLR pattern-recognition receptor (2006, background): “In healthy hosts, protection against fungal infection is generally thought to require a T H 1-cell immune response, which results in activation or potentiation of the fungicidal mechanisms of phagocytic cells, such as the respiratory burs”