Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

By Sonja I Gringhuis, Tanja M. Kaptein, B. Wevers, B. Theelen, M. Vlist, T. Boekhout, Teunis B. Geijtenbeek. Nature Immunology, 2012

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Caspases in cell death, inflammation and disease (2019, background): “Firstly, reports of proIL-1β maturation that is mediated directly by caspase-8 point to an inflammatory role for this apoptotic initiator caspase (Bossaller et al., 2012; Gringhuis et al., 2012; Maelfait et al., 2008; Vince et al., 2012).”
ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis) (2019, background): “While early studies indicated that caspase-8 could contribute to inflammatory functions by driving maturation of inflammatory IL-1 cytokines (Maelfait et al., 2008; Bossaller et al., 2012; Gringhuis et al., 2012; Vince et al., 2012; Man et al., 2014), Gurung et al.”
Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “Whereas the expression of pro-IL-1β can be triggered by the signaling and NFκB activation described above, the processing and activation of this cytokine require the activity of caspase-8, which complexes with ASC, CARD9, Bcl-10, and MALT-1 following Dectin-1 activation (145).”