Dectin-1 is required for β-glucan recognition and control of fungal infection

By P. Taylor, S. Tsoni, J. Willment, K. Dennehy, Marcela Rosas, Helen Findon, K. Haynes, C. Steele, M. Botto, S. Gordon and 1 more. Nature Immunology, 2006

1,219 citations recorded by the source corpus.

β-Glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that deficiency of dectin-1, the myeloid receptor for β-glucan, rendered mice susceptible to infection with Candida albicans. Dectin-1-deficient leukocytes demonstrated significantly impaired responses to fungi even in the presence of opsonins. Impaired leukocyte responses were manifested in vivo by reduced inflammatory cell recruitment after fungal infection, resulting in substantially increased fungal burdens and enhanced fungal dissemination. Our results establish a fundamental function for β-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non–Toll-like pattern-recognition receptor required for the induction of protective immune responses.

Subfields: Epidemiology, Infectious Diseases, Plant Science

View Paper: https://www.semanticscholar.org/paper/b0a23761ae50160e1f02ac8fd239edc080dc8bbb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. N. Gow
2. Mihai G. Netea
3. S. V. Van Dyken
4. R. Medzhitov
5. R. Locksley
6. Shizuo Akira
7. Kevin J. Tracey

In Infectious Diseases

1. N. Gow
2. Mihai G. Netea
3. S. V. Van Dyken
4. R. Medzhitov
5. R. Locksley

In Plant Science

1. N. Gow
2. Mihai G. Netea
3. R. Medzhitov

Citations in the corpus

• Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. (2010, neutral): “This was confirmed with three different strains, NBRC1385, SC5314, and THK519.”
• Candida albicans morphogenesis and host defence: discriminating invasion from colonization (2011, background): “The important role of dectin 1 and CARD9 in antifungal host defence has been confirmed by in vivo studie”
• Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “The major ligands for Dectin-1 are fungal β-1,3-glucans, and both mice and human studies confirmed a crucial role for this receptor in antifungal defense (123, 124).”
• Recognition of microorganisms and activation of the immune response (2007, background): “This PRR has an important role in antifungal defenc”
• Pattern recognition receptors and control of adaptive immunity (2009, neutral): “Furthermore, Dectin-1 signaling is critical for the clearance of fungal infections (35, 36).”
• INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, positive): “Dectin-1 (Clec7a) is an AAM-associated CLR that is expressed on macrophages, neutrophils, and DCs, among other cells, and is increasingly recognized as the principal PRR in mediating fungal recognition in mice (78, 79) and humans (80).”