Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.
By S. Saijo, S. Ikeda, K. Yamabe, S. Kakuta, H. Ishigame, A. Akitsu, N. Fujikado, T. Kusaka, Sachiko Kubo, S. Chung and 11 more. Immunity, 2010
738 citations recorded by the source corpus.
Subfields: Emergency Medical Services, Epidemiology, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/9dd0c3314e0e3925d1306589abdf31bef54ed78c
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In Epidemiology
Citations in the corpus
- Pattern recognition receptors in health and diseases (2021, background): “Dectin-2, which is different from Dectin-1, does not contain the ITAM sequence and has no signal transduction function.(182) Dectin2 mainly recognizes α-mannan in the fungal cell wall and recognizes the Schistosoma mansoni egg antigen.”
- Functional specialization of interleukin-17 family members. (2011, background): “albicans because only Il17a / mice, but not Il17f / mice, show increased susceptibility (Saijo et al., 2010).”
- Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “Dectin-2 binds α-mannans of fungal cell walls (146); however, it can also recognize other pathogens such as Schistosoma mansoni and Mycobacterium tuberculosis (127).”