INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE
By S. V. Van Dyken, R. Locksley. Annual Review of Immunology, 2013
671 citations recorded by the source corpus.
The macrophage, a versatile cell type prominently involved in host defense and immunity, assumes a distinct state of alternative activation in the context of polarized type 2 immune responses such as allergic inflammation and helminth infection. This alternatively activated phenotype is induced by the canonical type 2 cytokines interleukin (IL)-4 and IL-13, which mediate expression of several characteristic markers along with a dramatic shift in macrophage metabolic pathways that influence surrounding cells and tissues. We discuss recent advances in the understanding of IL-4- and IL-13-mediated alternatively activated macrophages and type 2 immune responses; such advances have led to an expanded appreciation for functions of these cells beyond immunity, including maintenance of physiologic homeostasis and tissue repair.
Subfields: Immunology, Physiology
View Paper: https://www.semanticscholar.org/paper/18eaaef4b1b2ed8f0cc7ff1fdb0606e0a5377124
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Citations in the corpus
- CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T Cell Checkpoint Immunotherapy in Pancreatic Cancer Models (2014, neutral): “than macrophages, including immature dendritic cells and monocytes (37).”
- Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, positive): “These gene regulatory pathways facilitate the recruitment of more immunoregulatory macrophages (M(IL-4)), release of immunoregulatory cytokines, and induction of processes like angiogenesis and basement membrane remodeling [29][30].”
- Cellular and molecular mechanisms of skin wound healing (2024, neutral): “M2 macrophage activation can be triggered by IL-4 and IL-13, typically secreted during the type 2 immune response by many cell types, including baso-phils, T helper 2 cells and T follicular helper cells 108,110,111 .”