Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line.

By T. Kondo, T. Setoguchi, T. Taga. Proceedings of the National Academy of Sciences of the United States of America, 2004

1,047 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/a53da7d8ca1d0c19310871e52038df311624a85b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. Richard J. Gilbertson
2. Angelo Luigi Vescovi
3. P. Dirks

In Genetics

1. David M. Berman
2. S. S. Karhadkar
3. Richard J. Gilbertson
4. Angelo Luigi Vescovi
5. P. Beachy

In Oncology

1. David M. Berman
2. S. S. Karhadkar
3. Richard J. Gilbertson
4. Angelo Luigi Vescovi
5. I. Clarke
6. Meenhard Herlyn
7. P. Beachy
8. P. Dirks

Citations in the corpus

• Isolation of cancer stem cells from adult glioblastoma multiforme (2004, methodology): “Although flow cytometric isolation of subpopulations of cells from tumors has been used (Al-Hajj et al., 2003; Singh et al., 2003; Kondo et al., 2004), there is no appropriate marker for isolating cancer stem cells, especially for distinguishing cancer stem cells from NSCs.”
• Tissue repair and stem cell renewal in carcinogenesis (2004, background): “In addition, cells with some of the properties of neural stem cells (NSCs), such as the ability to produce differentiated neurons and glia in vitro and in vivo and enhanced renewal activity, have recently been isolated from brain tumours and brain-tumour-derived cell line”
• Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. (2006, background): “EGFR FISH was performed using centromere 7 and an EGFR probe set ( Vysis ) .”
• Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma (2011, background): “are not true multipotent stem cells, but are a sub-population of highly tumorigenic cells that are theorized to contribute to chemoresistance and recurrence [198].”
• Tumour stem cells and drug resistance (2005, neutral): “Through the use of growth factors, investigators maintained these cells in culture, and showed that only the SP cells gave rise to both populations and produced cells with both neuronal and glial markers that were tumorigenic in mic”
• Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. (2006, background): “It has been shown that stem-like ‘‘side-populations’’ in established brain tumor cell lines are uniquely able to form xenografts (25, 26).”
• A perivascular niche for brain tumor stem cells. (2007, background): “CSCs have been identified in established brain tumor cell lines and are responsible for the in vivo malignancy of these cells (Kondo et al., 2004).”
• A tumorigenic subpopulation with stem cell properties in melanomas. (2005, background): “Stem-like cells were also found in an established glioma cell line by their inability to incorporate a nuclear dye (6, 7).”
• Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma (2004, neutral): “Thus, it is intriguing that Kondo et al. ( 50 ) have reported on the presence of tumorigenic stem-like cells in a rodent glioma cell line (C6) that require different growth factors than those used in previous studies to expand in culture.”