A tumorigenic subpopulation with stem cell properties in melanomas.

By D. Fang, Thiennga K. Nguyen, K. Leishear, R. Finko, A. Kulp, S. Hotz, P. V. Van Belle, Xiaowei Xu, D. Elder, Meenhard Herlyn. Cancer Research, 2005

1,338 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/24a22378706ee9d48ae3c07ee7f71d26407f1044

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In Molecular Biology

1. Alec C. Kimmelman
2. N. Bardeesy
3. R. DePinho
4. Piero Dalerba
5. Dalong Qian
6. Y. Shimono
7. N. Lobo
8. Robert W. Cho

In Oncology

1. Piero Dalerba
2. Dalong Qian
3. Y. Shimono
4. N. Lobo
5. Robert W. Cho
6. R. DePinho
7. H. Lai
8. M. Chan

Citations in the corpus

• Exploring the role of cancer stem cells in radioresistance (2008, background): “These data suggest that phenotypically distinct tumorigenic populations exist inside a tumou”
• Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, methodology): “Based on previous published reports regarding CSCs in solid tumors [7–21], the following markers were studied: CD24, CD44, CD133, and CD166.”
• Targeting cancer stem cell pathways for cancer therapy (2020, methodology): “59 After digestion of the tumor tissues into single cells, low-density cell culture can be conducted in serumfree medium containing epithelial growth factor (EGF) and basic fibroblast growth factor (FGF).”
• Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “…cells have also been described in solid organs, including cancer of the breast, brain, and prostate (Al-Hajj et al. 2003; Singh et al. 2004b; Collins et al. 2005), and candi- 1232 GENES & DEVELOPMENT dates have been found in lung neoplasia and melanoma (Fang et al. 2005; C.F. Kim et al. 2005).”
• Identification and characterization of ovarian cancer-initiating cells from primary human tumors. (2008, positive): “A small minority of cells could survive and form anchorage-independent clusters that subsequently coalesced into larger, self-renewing spheroids (14, 19, 27, 28) morphologically similar to spheroids isolated from patient ascites (20).”
• The biology of cancer stem cells. (2007, background): “Fang and colleagues (Fang et al. 2005) showed that 20% of the human melanomas evaluated contained a cancer-stem-cell-like fraction.”
• A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth (2010, methodology): “We previously reported that the B cell marker CD20 is indicative for self-renewal of melanoma spheres after propagation in stem cell medium (Fang et al., 2005).”
• Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment (2009, background): “The existence of CSCs was first proved in acute myeloid leukemia (6), and more recently in glioblastoma (7–9), melanoma (10, 11), and epithelial cancers (12–18).”
• Cancer stem cells: models and concepts. (2007, background): “In melanoma, in vitro culture of primary tumor cells with media formulations used for embryonic stem cells allows the isolation and serial propagation of “melanoma spheroids,” reminiscent of cancer neurospheres and capable of long-term self-renewal, multi-lineage differentiation and in vivo tumorige”