Isolation of cancer stem cells from adult glioblastoma multiforme

By Xiangpeng Yuan, James F Curtin, Yizhi Xiong, Gentao Liu, Sebastian Waschsmann-Hogiu, D. Farkas, K. Black, John S. Yu. Oncogene, 2004

830 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Oncology

View Paper: https://www.semanticscholar.org/paper/37c16126549a6670598f24793a38cc5a03bcb8eb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. Austin G Smith
2. Jeremy N. Rich
3. Richard J. Gilbertson
4. P. Dirks

In Genetics

1. Jeremy N. Rich
2. J. Lathia
3. Anita B. Hjelmeland
4. Eric C. Holland
5. Austin G Smith
6. Richard J. Gilbertson
7. G. Keller
8. Richard A. Young

In Oncology

1. Jeremy N. Rich
2. J. Lathia
3. Eric C. Holland
4. Anita B. Hjelmeland
5. Richard J. Gilbertson
6. I. Clarke
7. Meenhard Herlyn
8. P. Dirks

Citations in the corpus

• A tumorigenic subpopulation with stem cell properties in melanomas. (2005, background): “CSCs from brain tumors could be isolated, because they show in vitro growth characteristics similar to those of neural stem cells, which proliferate as nonadherent cell aggregates termed spheres or spheroids (8, 9).”
• Integrin alpha 6 regulates glioblastoma stem cells (2010, background): “…cells (CSCs), tumor-initiating cells, or tumor-propagating cells, has been found in many tumors (Reya et al., 2001) including brain cancers (Bao et al., 2006a, 2006b; Galli et al., 2004; Hemmati et al., 2003; Ignatova et al., 2002; Singh et al., 2003, 2004; Taylor et al., 2005; Yuan et al., 2004).”
• Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. (2009, background): “For all GNS cells analyzed and in contrast to glioma neurospheres (Yuan et al., 2004), we find that differentiation to oligodendrocytes (O4) or neurons (TuJ-1) is fully suppressed in the presence of EGF and FGF-2 (Figure 5A).”
• PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells (2009, background): “In recent years, numerous studies have reported the presence of stem cells in solid tumors referred to as cancer stem-like cells (Regenbrecht et al., 2008; Yuan et al., 2004).”
• Radial glia cells are candidate stem cells of ependymoma. (2005, background): “…sphere)-forming cells isolated from medulloblastoma and glioma express the neural stem cell marker CD133 and exhibit the ability to self-renew and differentiate along divergent neuronal lines (Hemmati et al., 2003; Ignatova et al., 2002; Singh et al., 2003; Uchida et al., 2000; Yuan et al., 2004).”
• Multicellular tumor spheroids: an underestimated tool is catching up again. (2010, background): “ducing tumors in athymic nude mice (Yuan et al., 2004).”
• Diffuse glioma growth: a guerilla war (2007, background): “Several studies suggest that gliomas are derived from neural stem cells (NSCs) or glial progenitor cells rather than from derailed mature glial cells [54, 162, 199].”