Molecular targets of dietary agents for prevention and therapy of cancer.

By Bharat B. Aggarwal, S. Shishodia. Biochemical Pharmacology, 2006

1,816 citations recorded by the source corpus.

Subfields: Molecular Medicine, Pharmacology, Plant Science

View Paper: https://www.semanticscholar.org/paper/a2ebf57323bcd450ac7ceae67bb0e47ed1077fa9

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In Pharmacology

In Plant Science

Citations in the corpus

Clove (Syzygium aromaticum): a precious spice. (2014, background): “This factor is activated by free radicals and results in the expression of gens that suppress apoptosis and induce cellular transformation, proliferation, invasion, metastasis among others[36].”
Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials (2008, neutral): “…c-Jun N-terminal kinases (JNKs), the extracellular signal-regulated kinases (ERKs), the p58 kinases, and the stress-activated protein kinases (SAPKs) (4, 45), although other studies have demonstrated that curcumin may facilitate apoptosis by inducing JNK and activating c-jun and c-abl (54, 126).”
Integrating cell-signalling pathways with NF-κB and IKK function (2007, background): “The growing appreciation of the role of NF-κB in human diseases is leading both to the development of inhibitors of this pathway and to an appreciation that many existing drugs and natural compounds function in part through their effects on IKK and NF-κB signallin”
Natural products and drug discovery (2009, background): “The Sushruta Samhita ( circa 600 BC) was mainly devoted to surgical practices, but also described 395 medicinal plants and 57 animal-derived products”
Natural polyphenols: An overview (2017, background): “Furthermore, green tea consumption has been proposed to greatly reduce the cancer risk of the bile duct,([66]) bladder,([67]) breast,([68]) and colon.”
Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy (2007, background): “Peer reviewed publications numbering in the 100 s have reiterated the potency of curcumin against a plethora of human cancer lines in the laboratory (selected reviews include [1,4-6,40,41]).”
Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment (2011, background): “The principal target molecules of internal pro-inflammatory factors responsible for mediating the inflammation are the free radicals, IL-1β, TNF-α, NF-κB, and NSAID-activated gene-1 (NAG-1) [53-55].”
Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells (2009, neutral): “It has been well known that dietary chemopreventive agents inhibit cancer cell growth in vitro and in vivo through the regulation of cell signaling transduction (21, 22).”
Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention (2009, background): “The National Cancer Institute, based on numerous reports describing anticancer activity, identified about 40 edible plants possessing cancer-preventive properties (20).”
Cancer preventive properties of ginger: a brief review. (2007, background): “Dietary agents consist of a wide variety of biologically active compounds that are ubiquitous in plants and many of them have been used as traditional medicines for thousands of years (Aggarwal and Shishodia, 2006).”
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. (2014, background): “Butein (3,4,2,4-tetrahydroxychalcone) is derived from numerous plants including stem bark of Semecarpus anacardium, Rhus verniciflua Stokes, and the heartwood of Dalbergia odorifera [196].”
The influence of population density and duration of breeding on broiler chickens productivity and profitability (2010, background): “Several dietary ingredients of the Zingiberaceae family have been reported and their biological activities elucidated (Aggarwal and Shishodia, 2006; Surh, 1999).”
Cancer is a Preventable Disease that Requires Major Lifestyle Changes (2008, background): “These phytochemicals have advantages because they are safe and usually target multiple cell-signaling pathways (71).”