Integrating cell-signalling pathways with NF-κB and IKK function

By N. Perkins. Nature reviews. Molecular cell biology, 2007

1,774 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/d7d34234a0872dbbfc86e91913f8c9ebc583dcb8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Zena Werb
2. Andrew J. Ewald
3. M. Egeblad
4. M. Gyrd-Hansen
5. A. Dinkova-Kostova
6. J. Hong
7. P. Meier
8. M. Park

In Immunology

1. Zena Werb
2. M. Gyrd-Hansen
3. A. Dinkova-Kostova
4. J. Hong
5. P. Meier
6. M. Park
7. Andrew J. Ewald
8. Gregory E. Miller

In Oncology

1. Zena Werb
2. M. Egeblad
3. Andrew J. Ewald
4. M. Krummel
5. B. Welm
6. Morgan L. Truitt
7. G. Peeters
8. H. Askautrud

Citations in the corpus

• Transcriptomic responses to heat stress and bleaching in the elkhorn coral Acropora palmata (2010, background): “The NF-κB family of transcription factors regulates genes that control cell death, cell adhesion, innate immunity, proliferation, inflammation, the cellular stress response, and tissue remodeling (Perkins 2007).”
• Oxidative Stress in Cancer (2020, background): “NF-κB represents a family of transcription factors that comprise heterodimer or homodimer combinations of p50, p52, p65/RelA, RelB, and c-Rel subunits, which provide an inducible first-line defense against infection and other damaging agents (Perkins, 2007).”
• Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma (2011, background): “NF- B expression is involved in cellular responses to stressful stimuli such as cytokines, UV irradiation, free radicals, hypoxia (including cigarette smoke) and infectious antigens [60-64].”
• IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer (2010, background): “Transcription factors of the NF-κB and Rel family are activated in response to receptor stimulation and various intracellular stressors, including DNA damag”
• Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches (2016, background): “The NF-κB transcription factor family in mammals consists of five proteins including p65 (RelA), RelB, c-Rel, p105/p50 (NF-κB1), and p100/52 (NF-κB2) that associate with each other to form distinct transcriptionally active homo- and heterodimeric complexes [13,14].”
• Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease (2015, neutral): “In the latter case, IKKβ, a regulator of the NF-κB pathway [287, 288], contains a conserved ETGE motif.”