Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment
By P. Basnet, N. Škalko-Basnet. Molecules, 2011
719 citations recorded by the source corpus.
Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer’s disease, etc. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and anti-inflammatory activities, might be a potential candidate for the prevention and/or treatment of cancer and other chronic diseases. However, curcumin, a highly pleiotropic molecule with an excellent safety profile targeting multiple diseases with strong evidence on the molecular level, could not achieve its optimum therapeutic outcome in past clinical trials, largely due to its low solubility and poor bioavailability. Curcumin can be developed as a therapeutic drug through improvement in formulation properties or delivery systems, enabling its enhanced absorption and cellular uptake. This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application of curcumin for the prevention and/or treatment of cancer.
Subfields: Endocrinology, Diabetes and Metabolism, Molecular Medicine, Pharmacology
View Paper: https://www.semanticscholar.org/paper/2cbab343d989faa0fdaf0a0ee22fa4aec63db0c0
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In Molecular Medicine
In Pharmacology
Citations in the corpus
- Curcumin: A Review of Its’ Effects on Human Health (2017, background): “Curcuminoids have been approved by the US Food and Drug Administration (FDA) as “Generally Recognized As Safe” (GRAS) [2], and good tolerability and safety profiles have been shown by clinical trials, even at doses between 4000 and 8000 mg/day [18] and of doses up to 12,000 mg/day of 95% concentrati”