Killing activity of neutrophils is mediated through activation of proteases by K+ flux

By E. Reeves, Hui-Chun Lu, H. Jacobs, C. Messina, S. Bolsover, G. Gabella, Eric Potma, A. Warley, J. Roes, A. Segal. Nature, 2002

1,198 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9c3ac3b4fb78bbc08733ef3750f119d79015d198

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Citations in the corpus

Diverse novel functions of neutrophils in immunity, inflammation, and beyond (2013, background): “Anthony Segal’s group proposed an interesting molecular interplay whereby ion fluxes triggered by the NADPH oxidase would promote the antimicrobial function of granule proteins (Reeves et al., 2002).”
Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica (2002, background): “We found that the genes encoding the defined transport systems for potassium were not induced, suggesting that high levels of potassium are present in the SCV, as has been reported for the phagocytic vacuole of neutrophils (Reeves et al., 2002).”
Hydrogen peroxide as second messenger in lymphocyte activation (2002, background): “Macrophages from mice deficient for the cysteine protease cathepsin G can no longer kill bacteria, although their oxidative burst is not impaire”
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “…to dissect the role of ROS production in bacterial killing by PMNs, as PMNs employ several bactericidal functions that act downstream of NADPH oxidase activation, including the release of NETs and activation of certain proteases (Reeves et al., 2002; Rada et al., 2004; Fuchs et al., 2007).”
How human neutrophils kill and degrade microbes: an integrated view (2007, background): “fumigatus (89) and Candida albicans (90) is compromised, whereas survival after infection with S.”
Microglia promote the death of developing Purkinje cells. (2004, methodology): “Furthermore, a recent analysis of microbicidal activity Animals Swiss mice were obtained from Janvier (Le Genest-St-Isle,of the phagocyte respiratory burst (Reeves et al., 2002) France).”
Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms (2006, background): “Furthermore, both oxygen-dependent (Wysong et al., 1989; Thompson and Wilton, 1992) and -independent mechanisms (Reeves et al., 2002; Newman et al., 2005) or the collaborative action of both (Hii et al., 1999) have been reported to be important for candidacidal activity of neutrophils underscoring…”
Neutrophil Elastase, Proteinase 3, and Cathepsin G as Therapeutic Targets in Human Diseases (2010, background): “(Reeves et al., 2002).”
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. (2006, background): “…pathways, including the mobilization of certain ions (such as K+) and proton consumption upon dismutation of ROS in the lumen of phagosomes, causing transient and strong alkalinization (Reeves et al., 2002), consistent with a rapid and transitory activation of NOX2 (Segal and Coade, 1978).”
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. (2007, background): “The activity of the phagocyte NADPH-oxidase also triggers opening of proton [8–11] and possibly potassium channels [3], that are proposed to change the ionic environment of the phagosome thereby activating microbicidal proteases and contributing to microbial killing [3].”
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies (2009, neutral): “The NOX2 NADPH oxidase has also been invoked in the activation of proteolytic enzymes by indirectly altering the ionic composition of phagosome”
Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species1 (2004, background): “Accumulation of H2O2, but not superoxide or NO, was a major contributor to this increased pool of ROS.”
Severity of E. coli mastitis is mainly determined by cow factors. (2003, background): “For each molecule of O2 consumed 4 O2 ions are generated, resulting in an intravacuolar O2 release of about 4 mol/L [194].”