Diverse novel functions of neutrophils in immunity, inflammation, and beyond

By A. Mócsai. Journal of Experimental Medicine, 2013

688 citations recorded by the source corpus.

Neutrophils have long been considered simple suicide killers at the bottom of the hierarchy of the immune response. That view began to change 10–20 yr ago, when the sophisticated mechanisms behind how neutrophils locate and eliminate pathogens and regulate immunity and inflammation were discovered. The last few years witnessed a new wave of discoveries about additional novel and unexpected functions of these cells. Neutrophils have been proposed to participate in protection against intracellular pathogens such as viruses and mycobacteria. They have been shown to intimately shape the adaptive immune response at various levels, including marginal zone B cells, plasmacytoid dendritic cells and T cell populations, and even to control NK cell homeostasis. Neutrophils have been shown to mediate an alternative pathway of systemic anaphylaxis and to participate in allergic skin reactions. Finally, neutrophils were found to be involved in physiological and pathological processes beyond the immune system, such as diabetes, atherosclerosis, and thrombus formation. Many of those functions appear to be related to their unique ability to release neutrophil extracellular traps even in the absence of pathogens. This review summarizes those novel findings on versatile functions of neutrophils and how they change our view of neutrophil biology in health and disease.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/a10af33444a5ad0246ee85832c2cba665e51826f

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In Immunology

1. Erin R Green
2. G. T. Nguyen
3. J. Mecsas
4. K. Futosi
5. Szabina Fodor
6. A. Mócsai

Citations in the corpus

• Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “Neutrophils participate in the development of various autoimmune and inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, blistering skin diseases, autoimmune vasculitides, anaphylactic reactions, aswell asmetabolic-vascular diseases such as atherosclerosis, thrombosi”
• Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. (2014, background): “Six / 2014 ow nloaded from http://m eridian.allenpress.com /doi/pdf/10.1563/aaid-joi-D -14-00138 by guest on 05 M ay 2020 murine model.43 These cells modulate the innate as well as adaptive immune response in a direct and indirect manner by crosstalk with B- and Tlymphocytes.44 Thus, the distributio”
• Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “…oxygen species (ROS) production, i.e., oxidative burst, is a powerful antimicrobial weapon, and a major component of the innate immune defense against bacterial and fungal infections (Dupre-Crochet et al., 2013; Mocsai, 2013; Paiva and Bozza, 2014; Kruger et al., 2015; Van Acker and Coenye, 2017).”