Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species1
By S. Kusmartsev, Yulia Nefedova, D. Yoder, D. Gabrilovich. Journal of Immunology, 2004
885 citations recorded by the source corpus.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/a4bc7572c51182600a12b900c9d27514576db75f
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In Immunology
- D. Gabrilovich
- M. Munder
- S. Ostrand-Rosenberg
- V. Bronte
- P. Sinha
- P. Rodriguez
- Augusto Ochoa
- Paola Zanovello
Citations in the corpus
- The tumor microenvironment at a glance (2012, background): “Indeed, they can even differentiate into TAMs (Kusmartsev et al., 2005; Kusmartsev et al., 2004).”
- NRF2 and the Hallmarks of Cancer. (2018, background): “MDSCs produce reactive nitrogen and oxygen species (RNOS) that prevent CD8+ T cell antigen recognition, a tolerance mechanism known as anergy (Kusmartsev et al., 2004, Nagaraj et al., 2007).”
- Arginase: an emerging key player in the mammalian immune system (2009, background): “MDSC can suppress T cell immune functions by constitutive expression of arginase with consecutive L-arginine depletion (Bronte et al., 2003; Liu et al., 2003; Kusmartsev et al., 2004; Rodriguez et al., 2004; Sinha et al., 2005; Gallina et al., 2006; Serafini et al., 2006b).”
- Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes (2009, positive): “Several reports have described the presence of a highly suppressive subpopulation of myeloid cells infiltrating mouse tumors, which has an increased arginase activity, depletes L-arginine, and blocks T-cell proliferation and cytokine production (6, 25, 26).”
- Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “Most reports indicate that Gr1 CD11b cells from tumor-free mice are not suppressive (21, 38, 41, 42, 50), although one study demonstrated that, on a per cell basis, Gr1 CD11b cells from tumor-bearing mice and tumor-free mice were equally suppressive (51).”