BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

By A. Shaffer, Xin Yu, Yunsheng He, Jennifer C. Boldrick, Erick P. Chan, Louis Staudt. Immunity, 2000

961 citations recorded by the source corpus.

Subfields: Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/9936b3f14084cd7e967947eab1e44e21d376a596

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. S. Kaech
2. C. Mackay
3. R. Dalla-Favera
4. Di Yu
5. B. Moser
6. M. Jutila
7. Carola G. Vinuesa
8. Jodi F. Hedges

In Pathology and Forensic Medicine

1. R. Dalla-Favera
2. U. Klein

Citations in the corpus

• The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. (2009, background): “Bcl-6 acts cell-autonomously in B cells to inhibit the terminal differentiation of GC B cells to plasma cells or memory cells, through the repression of Prdm1, the gene encoding Blimp-1 (Reljic et al., 2000; Shaffer et al., 2000).”
• Follicular B helper T cells in antibody responses and autoimmunity (2005, background): “In B cells, BCL-6 is a master regulator of germinal-centre lineage commitment that suppresses plasma-cell differentiatio”
• T follicular helper (TFH) cells in normal and dysregulated immune responses. (2008, background): “In B cells, Bcl-6 is a master regulator of GC lineage commitment and is a suppressor of plasma cell differentiation (61).”
• Pax5: the guardian of B cell identity and function (2007, background): “Similar to Pax5, the transcription factor Bcl6 is also involved in both the repression of Prdm1 as well as in the development of germinal-center B cell”
• The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells (2004, background): “The precise function of BCL6 in germinal-centre development and lymphomagenesis is unclear because very few direct BCL6 target genes have been identifie”
• T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells1 (2004, background): “vation, proliferation, and differentiation (24, 62).”
• Double-hit B-cell lymphomas. (2011, neutral): “Bertrand et al40 2007 10/17 (59) 1/10 (10) 58 (45-81) 7/10 (70) NA† NA NA NA 5/9 (56)‡”
• Regulation of plasma-cell development (2005, background): “A crucial function of BCL-6 is to repress BLIMP1 expression ( Figs 3 , 4 ), thereby allowing the germinal-centre reaction to continue for a sufficient duration before differentiation into plasma cells occur”
• Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D (2002, background): “binding element identified in the cyclin D2 promoter (41) lies”
• Serial Analysis of Gene Expression in Circulating γδ T Cell Subsets Defines Distinct Immunoregulatory Phenotypes and Unexpected Gene Expression Profiles (2003, background): “BLIMP-1 expression in cells is repressed by BCL-6, which also represses CD44 expression (44).”
• Germinal centres: role in B-cell physiology and malignancy (2008, background): “The identification of genes that are directly targeted for repression by BCL-6 has reinforced the notion of crucial and specialized functions for this protein in determining the GC phenotyp”