The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.

By Di Yu, Sudha Rao, Louis M. Tsai, S. K. Lee, Yi-qing He, E. Sutcliffe, Monika Srivastava, M. Linterman, Lei Zheng, N. Simpson and 7 more. Immunity, 2009

1,244 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/ea8f41127a42009708bce9c9007d3e434d72f19b

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In Immunology

Citations in the corpus

IL-6 in inflammation, immunity, and disease. (2014, background): “One of the target genes of this microRNA is B-cell lymphoma 6, which is known as an inhibitor of Th17-cell induction (Yu et al. 2009).”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “Certain miRNAs, such as the miR-17–92 cluster, might also be involved in the development and function of T follicular helper (T FH ) cells, which are specialized T cells that are dedicated to supporting B cells in germinal centres and facilitating antibody affinity maturation and class switchin”
Foxp3+ follicular regulatory T cells control T follicular helper cells and the germinal center response (2011, background): “Coordinated Bcl-6 and Blimp-1 expression in T FR cells Bcl-6, the transcriptional regulator of the T FH subset, regulates key molecules required for follicular localization and functio”
The regulation of IL-10 production by immune cells (2010, background): “In recent reports, BCL-6 was required for T follicular helper cell differentiation, but it inhibited the differentiation of other T H cell subsets, by direct interaction with T-bet, GATA3 and retinoic acid receptor-related orphan receptor-γt (RORγt”
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses (2010, background): “We have recently shown that Bcl-6 acts in a gene dose–dependent manner: halving the gene dose of Bcl6 reduced GCs after SRBC immunization by nearly 50% (Linterman et al., 2009b).”
Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion (2011, background): “In support of this hypothesis, only a fraction of tonsillar Tfh cells produces IL-4 together with IL-21 (Lane et al., 2005; Ma et al., 2009; Yu et al., 2009).”
Follicular Helper T Cells. (2016, background): “Intermediate expression of these molecules, particularly CXCR5, PD-1, ICOS, and SAP, marks a stage consistent with pre-GC Tfh cells (52, 55–57).”
T follicular helper cell differentiation, function, and roles in disease (2014, background): “…more than a decade ago, much of the interest in Tfh cells traces its origins to the identification of Bcl6 as an essential transcription factor in CD4+ T cells for Tfh cell differentiation and the development of germinal centers (GCs) (Johnston et al., 2009; Nurieva et al., 2009; Yu et al., 2009).”
T follicular helper cell biology: A decade of discovery and diseases (2019, background): “The TF Bcl6 is essential for Tfh differentiation, and constitutive ectopic expression of Bcl6 enhances Tfh differentiation (Hollister et al., 2013; Johnston et al., 2009; Nurieva et al., 2009; Yu et al., 2009).”