Germinal centres: role in B-cell physiology and malignancy

By U. Klein, R. Dalla-Favera. Nature reviews. Immunology, 2008

937 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/60abf6321d2164cb9db9d74cd3900a85e91cd819

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In Immunology

Citations in the corpus

B cells in HIV infection and disease (2009, background): “Tissue-like memory B cells also express decreased levels of CXCR4 and CXCR5, two chemokine receptors that are crucial for B-cell trafficking to germinal centres, where the maturation of T-cell-dependent B-cell responses occur”
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation (2013, background): “Such mutations can lead to the development of diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) (Alizadeh et al., 2000; Klein and Dalla-Favera, 2008).”
Discovery and Characterization of Super-Enhancer Associated Dependencies in Diffuse Large B-Cell Lymphoma (2013, neutral): “…protein) and BCL6, and additional genes with disproportionally BRD4-loaded enhancers such as PAX5 and IRF8 (Figure 4E), are essential for B-cell fate determination and germinal center formation (Basso and Dalla-Favera, 2012; Klein and Dalla-Favera, 2008; Teitell, 2003; Wang et al., 2008).”
From pathogenesis to treatment of chronic lymphocytic leukaemia (2010, background): “In addition to the combinatorial diversity of different segments, the BCR repertoire is increased by the introduction of somatic mutations through the somatic hypermutation (SHM) process during the germinal centre (GC) reaction ( Box 2 ) (reviewed in Ref”
Germinal Center Dynamics Revealed by Multiphoton Microscopy Using a Photoactivatable Fluorescent Reporter (2010, neutral): “…B cells known as centrocytes, as well as antigen deposited on the surface of follicular dendritic cells (FDCs) and antigenspecific follicular T helper cells (Allen et al., 2007a; Klein and Dalla-Favera, 2008;MacLennan, 1994; Nieuwenhuis andOpstelten, 1984; Rajewsky, 1996; Tarlinton, 2008).”
Evolution of the immune system in humans from infancy to old age (2015, neutral): “The evolution of antibody responses in B lymphocytes has been reviewed elsewhere in detail [64].”
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing (2012, background): “This physiologic process in B lymphocytes has been best studied at Ig gene loci, where it facilitates the development of antibody diversity (33), but other genes have been shown to be subject to aberrant SHM (including the PIM1 gene, in which we also observed hypermutation with 30 mutations in 16 pa”
Bcl6 dependent T follicular helper cell differentiation diverges from effector cell differentiation during priming and depends on the gene Icos (2011, neutral): “Bcl6 is a BTB domain containing transcriptional repressor previously known to be required in B cells for germinal center B cell differentiation, and Bcl6 is an important oncogene in germinal center B cell-derived lymphomas (Ci et al., 2008; Klein and Dalla-Favera, 2008).”