T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells1

By T. Chtanova, S. Tangye, R. Newton, N. Frank, M. Hodge, M. Rolph, C. Mackay. Journal of Immunology, 2004

601 citations recorded by the source corpus.

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Citations in the corpus

Cytokine-secreting follicular T cells shape the antibody repertoire (2009, methodology): “To ascertain whether IL-4-producing TFH cells were sufficient for IgG1 selection and affinity maturation, we isolated GFP+ or GFP+huCD2+ CD4+ T cells from 4get-KN2 mice immunized with chicken OVA haptenated with 15 NP molecules (OVA-NP(15)) and transferred the cells into naive mice deficient in both”
Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells1 (2005, methodology): “The following two indicators were used to assess the T vs B cell responses: CXCL13 production (a GC-Th cell response) (16, 24) and production of IgG and IgA (B cell responses).”
Bcl6 dependent T follicular helper cell differentiation diverges from effector cell differentiation during priming and depends on the gene Icos (2011, unknown): “Because PD-1 is a third canonical Tfh cell marker (Chtanova et al., 2004; Haynes et al., 2007; Linterman et al., 2009), we examined PD-1 expression.”
Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1 (2007, background): “Recent gene expression array studies identified additional genes that are up-regulated in CXCR5 T cells (7, 16, 17), including programmed cell death gene-1 (PD-1), a negative regulator of T cell activation (18).”
IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells1 (2005, background): “In humans, IL-21 has been shown to be produced by activated peripheral T cells, as well as spontaneously by CXCR5 follicular helper T cells (2, 6).”
Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “The transcriptional repressor Bcl-6 is expressed in Tfh cells (173), and recent reports have shown that Bcl-6 is dispensable for Tfh cell differentiation (174–176).”