Follicular B helper T cells in antibody responses and autoimmunity

By Carola G. Vinuesa, S. Tangye, B. Moser, C. Mackay. Nature reviews. Immunology, 2005

652 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2478dbadf6b9af1148e0531a1fa541d32787399f

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Citations in the corpus

Generation of follicular helper T cells is mediated by IL-21 but independent of TH1, TH2 or TH17 lineages (2008, background): “On the other hand, sanroque mice, which have a mutation in a RING-type E3 ubiquitin ligase, Roquin, developed spontaneous autoantibody production and lupus-like autoimmunity, associated with greatly increased numbers of CXCR5+CD4+ T cells and enhanced expression of IL-21 and ICOS (Vinuesa et al., 20”
Follicular Helper T Cells. (2016, background): “It has long been known that GC T cells are heterogeneous (206).”
Germinal Center Dynamics Revealed by Multiphoton Microscopy Using a Photoactivatable Fluorescent Reporter (2010, positive): “This notion is supported by previous work showing that dysregulated T cell help can lead to faulty GC selection and to the emergence of autoantibody-producing B cells (Vinuesa et al., 2005a; Kim et al., 2010).”
T follicular helper (TFH) cells in normal and dysregulated immune responses. (2008, background): “MOLECULES ASSOCIATED WITH TFH CELL FUNCTION The features of CXCR5+ TFH cells that distinguish them from Th1, Th2, Th17, or other T cells (42) are summarized in Figure 2.”
Foxp3+ follicular regulatory T cells control T follicular helper cells and the germinal center response (2011, background): “Selection of cognate germinal center B cells by T FH cells is one of the key mechanisms by which germinal center tolerance is regulate”
From Vaccines to Memory and Back (2010, neutral): “A dedicated subset of follicular helper T cells (T FH ) is required for induction of germinal center reactions that leads to differentiation of memory B cells and long lived plasma cells secreting high affinity antibodies of switched isotypes (Vinuesa et al., 2005).”
Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1 (2007, background): “However, some studies have found limited effects of IL-4 deficiency on the GC response, suggesting differential contributions of IL-4 depending on the type of response, perhaps reflecting redundancy in some cases with IL-21, a related cytokine expressed by follicular Th cells (50, 51).”
IL-17 and Th17 Cells. (2009, background): “, in T follicular helper cells (46) that express high levels of CXCR5 and ICOS (47).”
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. (2009, background): “…despite having a very distinct cell function compared to other effector T cells, they have a phenotype that is only distinguished from non-Tfh effectors by a quantitative increase in the expression of CXCR5, CXCR4, PD-1, ICOS, IL-21 and other molecules (King et al., 2008; Vinuesa et al., 2005b).”